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2.A.18.6.2
Liver histidine and glutamine specific system N-like, Na+-dependent amino acid transporter, mNAT. Also called SNAT3. SNAT3 trafficking occurs in a dynamin-independent manner and is influenced by caveolin (Balkrishna et al., 2010).

Accession Number:Q9DCP2
Protein Name:Sodium-coupled neutral amino acid transporter 3
Length:505
Molecular Weight:55592.00
Species: [10090]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Histidine, Glutamine

Cross database links:

Genevestigator: Q9DCP2
eggNOG: roNOG13316
HEGENOM: HBG443748
RefSeq: NP_076294.2   
Entrez Gene ID: 76257   
Pfam: PF01490   
KEGG: mmu:76257   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0015297 F:antiporter activity
GO:0015186 F:L-glutamine transmembrane transporter activity
GO:0005290 F:L-histidine transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0006868 P:glutamine transport
GO:0015817 P:histidine transport
GO:0006814 P:sodium ion transport

References (4)

[1] “Identification and characterization of an amino acid transporter expressed differentially in liver.”  Gu S.et.al.   10716701
[2] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Large-scale phosphorylation analysis of mouse liver.”  Villen J.et.al.   17242355

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEIPRQTEMV ELVPNGKHLE GLLPVGVPTT DTQRTEDTQH CGEGKGFLQK SPSKEPHFTD 
61:	FEGKTSFGMS VFNLSNAIMG SGILGLAYAM ANTGIILFLF LLTAVALLSS YSIHLLLKSS 
121:	GIVGIRAYEQ LGYRAFGTPG KLAAALAITL QNIGAMSSYL YIIKSELPLV IQTFLNLEKP 
181:	ASVWYMDGNY LVILVSVTII LPLALMRQLG YLGYSSGFSL SCMVFFLIAV IYKKFQVPCP 
241:	LAHNLANATG NFSHMVVAEE KAQLQGEPDT AAEAFCTPSY FTLNSQTAYT IPIMAFAFVC 
301:	HPEVLPIYTE LKDPSKRKMQ HISNLSIAVM YVMYFLAALF GYLTFYDGVE SELLHTYSKV 
361:	DPFDVLILCV RVAVLIAVTL TVPIVLFPVR RAIQQMLFQN QEFSWLRHVL IATGLLTCIN 
421:	LLVIFAPNIL GIFGIIGATS APCLIFIFPA IFYFRIMPTD KEPARSTPKI LALCFAAVGF 
481:	LLMTMSLSFI IIDWVSGTSQ HGGNH