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2.A.18.6.20
Vacuolar amino acid transporter 2

Accession Number:P39981
Protein Name:Vacuolar amino acid transporter 2
Length:480
Molecular Weight:53324.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

Genevestigator: P39981
eggNOG: COG0814
HEGENOM: HOG000188354
DIP: DIP-5166N
Entrez Gene ID: 856645   
Pfam: PF01490   
KEGG: sce:YEL064C   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0016021 C:integral to membrane
GO:0005774 C:vacuolar membrane
GO:0005215 F:transporter activity
GO:0006865 P:amino acid transport

References (3)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome V.”  Dietrich F.S.et.al.   9169868
[2] “Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE.”  Zhang Z.et.al.   15905473
[3] “A family of yeast proteins mediating bidirectional vacuolar amino acid transport.”  Russnak R.et.al.   11274162

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSELGEYSKL ENKELRTEFE LTNFPFPGTT DNDSDDGSQG QNSLNIITPD MDDTLVNDVL 
61:	RENDKKSSMR MAFMNLANSI LGAGIITQPF AIKNAGILGG LLSYVALGFI VDWTLRLIVI 
121:	NLTLAGKRTY QGTVEHVMGK KGKLLILFTN GLFAFGGCIG YCIIIGDTIP HVLRAIFSQN 
181:	DGNVHFWLRR NVIIVMVTTF ISFPLSMKRN IEALSKASFL AVISMIIIVL TVVIRGPMLP 
241:	YDWKGHSLKL SDFFMKATIF RSLSVISFAL VCHHNTSFIF FSMRNRSVAK FTRLTHISII 
301:	ISVICCALMG YSGFAVFKEK TKGNVLNSFP GTDTAINIAR LCFGFNMLTT FPMEIFVLRD 
361:	VVGNLLHECN LIKNYDEHTQ LSGKQHVVIT SSLVFITMGI SLTTCNLGAL FELIGATTAS 
421:	TMAYILPPYT NLLLTSKKKS WKERLPFYLC ICFGFMIMII SSTQTIIDAV NGSDGQHCQI