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2.A.18.6.3
System N1, SNAT3 [glutamine/histidine/asparagine/alanine]:[Na+ + H+] sym/antiporter (1 aa + 2 Na+ cotransported against 1 H+ antiported out) (probable orthologue of mNAT). Li+ can substitute for Na+; system N1 can function bidirectionally. SNAT3 is a primarily a glutamine transporter required for amino acid homeostasis. Loss cannot be compensated, suggesting that this transporter is a major route of glutamine transport in the liver, brain, and kidney (Chan et al. 2015).

Accession Number:Q99624
Protein Name:SN1 aka G17
Length:504
Molecular Weight:55773.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Glutamine, Histidine, Asparagine, Alanine, Na+, H+

Cross database links:

Genevestigator: Q99624 Q99624
eggNOG: prNOG06771
RefSeq: NP_006832.1   
Entrez Gene ID: 10991   
Pfam: PF01490   
Drugbank: Drugbank Link   
OMIM: 604437  gene
KEGG: hsa:10991    hsa:10991   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0015297 F:antiporter activity
GO:0015180 F:L-alanine transmembrane transporter activity
GO:0015182 F:L-asparagine transmembrane transporter acti...
GO:0015186 F:L-glutamine transmembrane transporter activity
GO:0005290 F:L-histidine transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0006867 P:asparagine transport
GO:0006868 P:glutamine transport
GO:0015817 P:histidine transport
GO:0015808 P:L-alanine transport
GO:0006814 P:sodium ion transport
GO:0015182 F:L-asparagine transmembrane transporter activity
GO:0006811 P:ion transport

References (12)

[1] “Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter.”  Fei Y.-J.et.al.   10823827
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[4] “The DNA sequence, annotation and analysis of human chromosome 3.”  Muzny D.M.et.al.   16641997
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes.”  Lerman M.I.et.al.   11085536
[7] “Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter.”  Fei Y.-J.et.al.   10823827
[8] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[9] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[10] “The DNA sequence, annotation and analysis of human chromosome 3.”  Muzny D.M.et.al.   16641997
[11] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[12] “The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes.”  Lerman M.I.et.al.   11085536

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEAPLQTEMV ELVPNGKHSE GLLPVITPMA GNQRVEDPAR SCMEGKSFLQ KSPSKEPHFT 
61:	DFEGKTSFGM SVFNLSNAIM GSGILGLAYA MANTGIILFL FLLTAVALLS SYSIHLLLKS 
121:	SGVVGIRAYE QLGYRAFGTP GKLAAALAIT LQNIGAMSSY LYIIKSELPL VIQTFLNLEE 
181:	KTSDWYMNGN YLVILVSVTI ILPLALMRQL GYLGYSSGFS LSCMVFFLIA VIYKKFHVPC 
241:	PLPPNFNNTT GNFSHVEIVK EKVQLQVEPE ASAFCTPSYF TLNSQTAYTI PIMAFAFVCH 
301:	PEVLPIYTEL KDPSKKKMQH ISNLSIAVMY IMYFLAALFG YLTFYNGVES ELLHTYSKVD 
361:	PFDVLILCVR VAVLTAVTLT VPIVLFPVRR AIQQMLFPNQ EFSWLRHVLI AVGLLTCINL 
421:	LVIFAPNILG IFGVIGATSA PFLIFIFPAI FYFRIMPTEK EPARSTPKIL ALCFAMLGFL 
481:	LMTMSLSFII IDWASGTSRH GGNH