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2.A.18.6.6
The vacuolar amino acid transporter, AVT6 (catalyzes efflux from yeast vacuoles of acidic amino acids, Asp and Glu)

Accession Number:P40074
Protein Name:AVT6 aka YER119C
Length:448
Molecular Weight:48840.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

Genevestigator: P40074
eggNOG: fuNOG04087
HEGENOM: HBG332582
DIP: DIP-4489N
RefSeq: NP_011044.1   
Entrez Gene ID: 856855   
Pfam: PF01490   
KEGG: sce:YER119C   

Gene Ontology

GO:0000329 C:fungal-type vacuole membrane
GO:0016021 C:integral to membrane
GO:0015183 F:L-aspartate transmembrane transporter activity
GO:0005313 F:L-glutamate transmembrane transporter activity
GO:0005515 F:protein binding
GO:0032974 P:amino acid export from vacuole

References (5)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome V.”  Dietrich F.S.et.al.   9169868
[2] “Sequence, map position and genome organization of the RPL17B gene, encoding ribosomal protein L17b in Saccharomyces cerevisiae.”  Berroteran R.W.et.al.   7668045
[3] “A family of yeast proteins mediating bidirectional vacuolar amino acid transport.”  Russnak R.et.al.   11274162
[4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[5] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVASIRSGVL TLLHTACGAG ILAMPYAFKP FGLIPGVIMI VLCGACAMQS LFIQARVAKY 
61:	VPQGRASFSA LTRLINPNLG IVFDLAIAIK CFGVGVSYMI VVGDLMPQIM SVWTRNAWLL 
121:	NRNVQISLIM LFFVAPLSFL KKLNSLRYAS MVAISSVAYL CVLVLLHYVA PSDEILRLKG 
181:	RISYLLPPQS HDLNVLNTLP IFVFAYTCHH NMFSIINEQR SSRFEHVMKI PLIAISLALI 
241:	LYIAIGCAGY LTFGDNIIGN IIMLYPQAVS STIGRIAIVL LVMLAFPLQC HPARASIHQI 
301:	LQHFAEENVS ISATSADEPT VATESSPLIR DSSLDLNEVI EEESIYQPKE TPLRGKSFIV 
361:	ITCSILVASY LVAISVSSLA RVLAIVGATG STSISFILPG LFGYKLIGTE HKTAVPLTTK 
421:	IFKYTGLLLF IWGLIIMITC LTAALKLN