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2.A.18.6.7
The Na-dependent alanine/α-(methylamino) isobutyric acid-transporting system A, ATA3 or SNAT4. Transports most neutral short chain amino acids electrogenically. Present only in liver and skeletal muscle. 47% and 57% identical to ATA1 and ATA2, respectively. A 10TMS topology [with N-and C-termini outside and a large N-glycosylated, extracellular loop domain (residues 242-335)] has been established (Shi et al., 2011). (Km(ALA)= 4mM; Na+:Ala= 1:1) (Sugawara et al., 2000)

Accession Number:Q9EQ25
Protein Name:Sodium-coupled neutral amino acid transporter 4 aka ATA3
Length:547
Molecular Weight:60613.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Alanine, Alpha-methylaminoisobutyric acid, Na+

Cross database links:

Genevestigator: Q9EQ25
eggNOG: roNOG09331
RefSeq: NP_570104.1   
Entrez Gene ID: 170573   
Pfam: PF01490   
KEGG: rno:170573   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0006865 P:amino acid transport
GO:0006814 P:sodium ion transport

References (2)

[1] “Structure and function of ATA3, a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle.”  Sugawara M.et.al.   11118514
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDPIELRSVN IEPYEDSCSV DSIQSCYTGM GNSEKGAMDS QFANEDAESQ KFLTNGFLGK 
61:	KTLTDYADEH HPGTTSFGMS SFNLSNAIMG SGILGLSYAM ANTGIVLFVI MLLTVAILSL 
121:	YSVHLLLKTA KEGGSLIYEK LGEKAFGWPG KIGAFISITM QNIGAMSSYL FIIKYELPEV 
181:	IRVFMGLEEN TGEWYLNGNY LVLFVSVGII LPLSLLKNLG YLGYTSGFSL TCMVFFVSVV 
241:	IYKKFQIPCP LPVLDHNNGN LTFNNTLPMH VIMLPNNSES TGMNFMVDYT HRDPEGLDEK 
301:	PAAGPLHGSG VEYEAHSGDK CQPKYFVFNS RTAYAIPILA FAFVCHPEVL PIYSELKDRS 
361:	RRKMQTVSNI SITGMLVMYL LAALFGYLSF YGEVEDELLH AYSKVYTFDT ALLMVRLAVL 
421:	VAVTLTVPIV LFPIRTSVIT LLFPRRPFSW VKHFGIAAII IALNNVLVIL VPTIKYIFGF 
481:	IGASSATMLI FILPAAFYLK LVKKEPLRSP QKIGALVFLV TGIIFMMGSM ALIIIDWIYN 
541:	PPNPDHH