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2.A.18.6.8
Second subtype of system N; glutamine transporter, SN2. Prevalent in liver, but detectable in other tissues. Amino acid uptake is coupled to Na+ influx and H+ efflux (Nakanishi et al., 2001)

Accession Number:A2VCW5
Protein Name:Sodium-coupled neutral amino acid transporter 5
Length:479
Molecular Weight:52436.00
Species: [10116]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Glutamine, Na+, H+

Cross database links:

Genevestigator: A2VCW5
eggNOG: roNOG08283
RefSeq: NP_620209.1   
Entrez Gene ID: 192208   
Pfam: PF01490   
KEGG: rno:192208   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015187 F:glycine transmembrane transporter activity
GO:0015816 P:glycine transport

References (4)

[1] “Cloning and functional characterization of a new subtype of the amino acid transport system N.”  Nakanishi T.et.al.   11698233
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Amino acid transporter SNAT5 localizes to glial cells in the rat brain.”  Cubelos B.et.al.   15390093
[4] “Evidence for allosteric regulation of pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity involving a conserved histidine residue.”  Baird F.E.et.al.   16629640

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAISCAVGME MQEPKMNGTL STGAAAGYRQ EREGFLPTTH GPAPGRKPVQ FLDFEGKTSF 
61:	GMSVFNLSNA IMGSGILGLA YAMAHTGVIF FLALLLCIAL LSSYSIHLLL TCASVVGIRA 
121:	YEQLGQRAFG PAGKVVVAII ICLHNVGAMS SYLFIIKSEL PLVIGTFLHM DPEGDWFLKG 
181:	NLLIILVSLL IILPLALMKH LGYLGYTSSL SLTCMLFFLI SVIYKKFQLG CVVSHNDTVV 
241:	ESEPAPLQAF NSSCEAKLFT VDSQMSYTVP IMAFAFVCHP EVLPIYTELC CPTQRRMQAV 
301:	ANMSIGAMFI MYGLTATFGY LTFYSTVKAE MLEMYTQEDL LILCVRLAVL LAVTLTVPVV 
361:	LFPIRRALQQ LLFPSKAFSW PRHVAIALIL LILVNILVIC VPTIRDIFGF IGSTSAPSLI 
421:	FILPSVFYLR IVPADMEPLF SWPKIQALCF GVLGVLFMAI SLGFMFANWA TGQSRMSGH