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2.A.18.7.3
Vacuolar amino acid transporter 3, Avt3.  Catalyzes efflux from vacuoles of large hydrophobic and hydrophilic neutral amino acids, and is required for sporulation.

Accession Number:Q10074
Protein Name:Vacuolar amino acid transporter 3
Length:656
Molecular Weight:73061.00
Species:Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [284812]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

eggNOG: COG0814
HEGENOM: HOG000185918
Entrez Gene ID: 2543612   
Pfam: PF01490   
KEGG: spo:SPAC3H1.09c   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0005789 C:endoplasmic reticulum membrane
GO:0000329 C:fungal-type vacuole membrane
GO:0016021 C:integral to membrane
GO:0034639 F:L-amino acid efflux transmembrane transporter activity
GO:0032974 P:amino acid export from vacuole
GO:0006995 P:cellular response to nitrogen starvation
GO:0030435 P:sporulation resulting in formation of a cellular spore

References (4)

[1] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360
[2] “ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.”  Matsuyama A.et.al.   16823372
[3] “Phosphoproteome analysis of fission yeast.”  Wilson-Grady J.T.et.al.   18257517
[4] “Autophagy-deficient Schizosaccharomyces pombe mutants undergo partial sporulation during nitrogen starvation.”  Mukaiyama H.et.al.   19778961

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSNSQSIKIK KPRSNENFAS GSYSSRRSQQ IHRLSHSPMA EGFHKPKLNI SPSESNLPNN 
61:	VAENTTDTPV NYGSIRDENH NSRKGKDVTL NSDEAHSENV PSTSEDPDVV RRHLGGQAAD 
121:	DDNFSSLQLQ GGDMHRQVYR WQQEVDQNKQ IRRGRSRSFS AKVSDPNLHL RSVQDMKQAG 
181:	GMRRDFLRNR ASSISMSSNA HGNPNFLNRN FIEFLSVYGH FAGEELSEED EDEDTDDFAM 
241:	PRDVNPSLIH STVPSEQEPL ISRHGRYKLQ TPGNASNGKA VLLLLKSFVG TGVLFLPKAF 
301:	KLGGLVFSSA TLLIVGVLSH ICFLLLIQTR MKVPGSFGDI GGTLYGPHMR FAILASIVVS 
361:	QIGFSSAYIS FVASTLQACV KVISTTHREY HLAVFIFIQF LVFVPLSLVR KISKLSATAL 
421:	IADVFILLGI LYLYFWDVIT LATKGIADVA MFNKTDFSLF IGVAIFTYEG ICLILPIQEQ 
481:	MAKPKNLPKL LTGVMAAISL LFISIGLLSY AAFGSKVKTV VILNMPESTF TVIIQFLYAI 
541:	AILLSTPLQL FPAIAIIEQG IFTRSGKRNR KIKWRKNYLR VLIVILAILI SWAGSSRLDL 
601:	FVSMVGSVCC IPLIYMYPPM LHYKACANNW ILRTLDIFMF TIGAFAMAFT TYMTFF