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2.A.18.8.4
H+-coupled amino acid transporter-3 (SLC36A3).  SLC36A3 is expressed only in testes and has no known function (Thwaites and Anderson 2011).

Accession Number:Q495N2
Protein Name:Proton-coupled amino acid transporter 3
Length:470
Molecular Weight:51735.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Amino acids, H+

Cross database links:

Genevestigator: Q495N2 Q495N2 Q495N2
eggNOG: COG0814 COG0814 COG0814
HEGENOM: HOG000006823 HOG000006823 HOG000006823
Entrez Gene ID: 285641   
Pfam: PF01490   
KEGG: hsa:285641    hsa:285641    hsa:285641   

Gene Ontology

GO:0016021 C:integral to membrane

References (15)

[1] “A cluster of proton/amino acid transporter genes in the human and mouse genomes.”  Boll M.et.al.   12809675
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Organization and expression of the SLC36 cluster of amino acid transporter genes.”  Bermingham J.R. Jr.et.al.   15058382
[5] “Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling.”  Wang Y.et.al.   17053785
[6] “A cluster of proton/amino acid transporter genes in the human and mouse genomes.”  Boll M.et.al.   12809675
[7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “Organization and expression of the SLC36 cluster of amino acid transporter genes.”  Bermingham J.R. Jr.et.al.   15058382
[10] “Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling.”  Wang Y.et.al.   17053785
[11] “A cluster of proton/amino acid transporter genes in the human and mouse genomes.”  Boll M.et.al.   12809675
[12] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[13] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[14] “Organization and expression of the SLC36 cluster of amino acid transporter genes.”  Bermingham J.R. Jr.et.al.   15058382
[15] “Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling.”  Wang Y.et.al.   17053785

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSLLGRDYNS ELNSLDNGPQ SPSESSSSIT SENVHPAGEA GLSMMQTLIH LLKCNIGTGL 
61:	LGLPLAIKNA GLLVGPVSLL AIGVLTVHCM VILLNCAQHL SQRLQKTFVN YGEATMYGLE 
121:	TCPNTWLRAH AVWGRYTVSF LLVITQLGFC SVYFMFMADN LQQMVEKAHV TSNICQPREI 
181:	LTLTPILDIR FYMLIILPFL ILLVFIQNLK VLSVFSTLAN ITTLGSMALI FEYIMEGIPY 
241:	PSNLPLMANW KTFLLFFGTA IFTFEGVGMV LPLKNQMKHP QQFSFVLYLG MSIVIILYIL 
301:	LGTLGYMKFG SDTQASITLN LPNCWLYQSV KLMYSIGIFF TYALQFHVPA EIIIPFAISQ 
361:	VSESWALFVD LSVRSALVCL TCVSAILIPR LDLVISLVGS VSSSALALII PALLEIVIFY 
421:	SEDMSCVTIA KDIMISIVGL LGCIFGTYQA LYELPQPISH SMANSTGVHA