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2.A.18.8.5
H+-coupled amino acid transporter-4; SLC36A4.  SLC36A4 is widely distributed  and has high-affinity (Km = 2-3 µM) for proline and tryptophan (Thwaites and Anderson 2011).

Accession Number:Q6YBV0
Protein Name:Proton-coupled amino acid transporter 4
Length:504
Molecular Weight:56157.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Amino acids, H+

Cross database links:

Genevestigator: Q6YBV0 Q6YBV0 Q6YBV0
eggNOG: COG0814 COG0814 COG0814
HEGENOM: HOG000006823 HOG000006823 HOG000006823
Entrez Gene ID: 120103   
Pfam: PF01490   
KEGG: hsa:120103    hsa:120103    hsa:120103   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015293 F:symporter activity
GO:0015808 P:L-alanine transport
GO:0015824 P:proline transport
GO:0015827 P:tryptophan transport

References (9)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes.”  Pillai S.M.et.al.   21097500
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes.”  Pillai S.M.et.al.   21097500
[7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes.”  Pillai S.M.et.al.   21097500

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MEAAATPAAA GAARREELDM DVMRPLINEQ NFDGTSDEEH EQELLPVQKH YQLDDQEGIS 
61:	FVQTLMHLLK GNIGTGLLGL PLAIKNAGIV LGPISLVFIG IISVHCMHIL VRCSHFLCLR 
121:	FKKSTLGYSD TVSFAMEVSP WSCLQKQAAW GRSVVDFFLV ITQLGFCSVY IVFLAENVKQ 
181:	VHEGFLESKV FISNSTNSSN PCERRSVDLR IYMLCFLPFI ILLVFIRELK NLFVLSFLAN 
241:	VSMAVSLVII YQYVVRNMPD PHNLPIVAGW KKYPLFFGTA VFAFEGIGVV LPLENQMKES 
301:	KRFPQALNIG MGIVTTLYVT LATLGYMCFH DEIKGSITLN LPQDVWLYQS VKILYSFGIF 
361:	VTYSIQFYVP AEIIIPGITS KFHTKWKQIC EFGIRSFLVS ITCAGAILIP RLDIVISFVG 
421:	AVSSSTLALI LPPLVEILTF SKEHYNIWMV LKNISIAFTG VVGFLLGTYI TVEEIIYPTP 
481:	KVVAGTPQSP FLNLNSTCLT SGLK