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2.A.18.8.6
Proton-coupled amino acid transporter 2 (Proton/amino acid transporter 2) (Solute carrier family 36 member 2) (Tramdorin-1)

Accession Number:Q495M3
Protein Name:Proton-coupled amino acid transporter 2
Length:483
Molecular Weight:53216.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Amino acids, H+

Cross database links:

Genevestigator: Q495M3
eggNOG: COG0814
HEGENOM: HOG000006823
Entrez Gene ID: 153201   
Pfam: PF01490   
KEGG: hsa:153201   

Gene Ontology

GO:0005737 C:cytoplasm
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015187 F:glycine transmembrane transporter activity
GO:0005280 F:hydrogen:amino acid symporter activity
GO:0015180 F:L-alanine transmembrane transporter activity
GO:0015193 F:L-proline transmembrane transporter activity
GO:0006811 P:ion transport
GO:0035524 P:proline transmembrane transport

References (5)

[1] “A cluster of proton/amino acid transporter genes in the human and mouse genomes.”  Boll M.et.al.   12809675
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Organization and expression of the SLC36 cluster of amino acid transporter genes.”  Bermingham J.R. Jr.et.al.   15058382
[5] “Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters.”  Broer S.et.al.   19033659

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSVTKSTEGP QGAVAIKLDL MSPPESAKKL ENKDSTFLDE SPSESAGLKK TKGITVFQAL 
61:	IHLVKGNMGT GILGLPLAVK NAGILMGPLS LLVMGFIACH CMHILVKCAQ RFCKRLNKPF 
121:	MDYGDTVMHG LEANPNAWLQ NHAHWGRHIV SFFLIITQLG FCCVYIVFLA DNLKQVVEAV 
181:	NSTTNNCYSN ETVILTPTMD SRLYMLSFLP FLVLLVLIRN LRILTIFSML ANISMLVSLV 
241:	IIIQYITQEI PDPSRLPLVA SWKTYPLFFG TAIFSFESIG VVLPLENKMK NARHFPAILS 
301:	LGMSIVTSLY IGMAALGYLR FGDDIKASIS LNLPNCWLYQ SVKLLYIAGI LCTYALQFYV 
361:	PAEIIIPFAI SRVSTRWALP LDLSIRLVMV CLTCLLAILI PRLDLVISLV GSVSGTALAL 
421:	IIPPLLEVTT FYSEGMSPLT IFKDALISIL GFVGFVVGTY QALDELLKSE DSHPFSNSTT 
481:	FVR