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2.A.18.8.7
Proton-coupled amino acid transporter 1 (Proton/amino acid transporter 1) (hPAT1 or LYAAT-1) (Solute carrier family 36 member 1).  SLC36A1 is expressed at the luminal surface of the small intestine but is also commonly found in lysosomes in many cell types (including neurons), suggesting that it is a multipurpose carrier with distinct roles in different cells including absorption in the small intestine and as an efflux pathway following intralysosomal protein breakdown. SLC36A1 has a relatively low affinity (Km = 1-10 mM) for its substrates, which include zwitterionic amino and imino acids, heterocyclic amino acids and amino acid-based drugs and derivatives used experimentally and/or clinically to treat epilepsy, schizophrenia, bacterial infections, hyperglycaemia and cancer (Thwaites and Anderson 2011).  hPAT1 transports the pyridine alkaloids, arecaidine, guvacine and isoguvacine, across the apical membrane of enterocytes and might be responsible for the intestinal absorption of these drug candidates (Voigt et al. 2013).

Accession Number:Q7Z2H8
Protein Name:Proton-coupled amino acid transporter 1
Length:476
Molecular Weight:53076.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Amino acids, H+

Cross database links:

Genevestigator: Q7Z2H8
eggNOG: COG0814
Entrez Gene ID: 206358   
Pfam: PF01490   
Drugbank: Drugbank Link   
KEGG: hsa:206358   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0016021 C:integral to membrane
GO:0005765 C:lysosomal membrane
GO:0005886 C:plasma membrane
GO:0015187 F:glycine transmembrane transporter activity
GO:0015078 F:hydrogen ion transmembrane transporter activity
GO:0015180 F:L-alanine transmembrane transporter activity
GO:0015193 F:L-proline transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0006865 P:amino acid transport
GO:0006811 P:ion transport
GO:0055085 P:transmembrane transport

References (6)

[1] “A cluster of proton/amino acid transporter genes in the human and mouse genomes.”  Boll M.et.al.   12809675
[2] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[3] “The DNA sequence and comparative analysis of human chromosome 5.”  Schmutz J.et.al.   15372022
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “Integral and associated lysosomal membrane proteins.”  Schroeder B.et.al.   17897319
[6] “Identification of a disulfide bridge essential for transport function of the human proton-coupled amino acid transporter hPAT1.”  Dorn M.et.al.   19549785

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSTQRLRNED YHDYSSTDVS PEESPSEGLN NLSSPGSYQR FGQSNSTTWF QTLIHLLKGN 
61:	IGTGLLGLPL AVKNAGIVMG PISLLIIGIV AVHCMGILVK CAHHFCRRLN KSFVDYGDTV 
121:	MYGLESSPCS WLRNHAHWGR RVVDFFLIVT QLGFCCVYFV FLADNFKQVI EAANGTTNNC 
181:	HNNETVILTP TMDSRLYMLS FLPFLVLLVF IRNLRALSIF SLLANITMLV SLVMIYQFIV 
241:	QRIPDPSHLP LVAPWKTYPL FFGTAIFSFE GIGMVLPLEN KMKDPRKFPL ILYLGMVIVT 
301:	ILYISLGCLG YLQFGANIQG SITLNLPNCW LYQSVKLLYS IGIFFTYALQ FYVPAEIIIP 
361:	FFVSRAPEHC ELVVDLFVRT VLVCLTCILA ILIPRLDLVI SLVGSVSSSA LALIIPPLLE 
421:	VTTFYSEGMS PLTIFKDALI SILGFVGFVV GTYEALYELI QPSNAPIFIN STCAFI