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2.A.19.2.5
High affinity vacuolar (tonoplast) Ca2+:H+ antiporter (also exports Cd2+ and Zn2+; Shigaki et al., 2005) highly expressed in roots (Cheng et al., 2005) (exhibits phenotypes characteristic of CAX1, but also determines sensitivities to salt, lithium and low pH (Zhao et al., 2008)

Accession Number:Q93Z81
Protein Name:Cax3
Length:459
Molecular Weight:49851.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate Ca2+, Cd2+, Zn2+, H+

Cross database links:

Genevestigator: Q93Z81
eggNOG: KOG1397
HEGENOM: HBG738140
RefSeq: NP_190754.2   
Entrez Gene ID: 824349   
Pfam: PF01699   
KEGG: ath:AT3G51860   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0009705 C:plant-type vacuole membrane
GO:0015369 F:calcium:hydrogen antiporter activity
GO:0005515 F:protein binding
GO:0006816 P:calcium ion transport
GO:0006874 P:cellular calcium ion homeostasis
GO:0030026 P:cellular manganese ion homeostasis
GO:0006882 P:cellular zinc ion homeostasis
GO:0010351 P:lithium ion transport
GO:0006793 P:phosphorus metabolic process
GO:0051592 P:response to calcium ion
GO:0009624 P:response to nematode
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (6)

[1] “Characterization of CAX-like genes in plants: implications for functional diversity.”  Shigaki T.et.al.   11080595
[2] “Fine sequence analysis of 60 kb around the Arabidopsis thaliana AtEm1 locus on chromosome III.”  Comella P.et.al.   10645728
[3] “Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.”  Salanoubat M.et.al.   11130713
[4] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[5] “Structural determinants of Ca2+ transport in the Arabidopsis H+/Ca2+ antiporter CAX1.”  Shigaki T.et.al.   11562366
[6] “Functional association of Arabidopsis CAX1 and CAX3 is required for normal growth and ion homeostasis.”  Cheng N.-H.et.al.   16055687

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGSIVEPWAA IAENGNANVT AKGSSRELRH GRTAHNMSSS SLRKKSDLRL VQKVPCKTLK 
61:	NILSNLQEVI LGTKLTLLFL AIPLAILANS YNYGRPLIFG LSLIGLTPLA ERVSFLTEQL 
121:	AFYTGPTVGG LLNATCGNAT ELIIAILALA NNKVAVVKYS LLGSILSNLL LVLGTSLFFG 
181:	GIANIRREQR FDRKQADVNF FLLLMGLLCH LLPLLLKYAA TGEVSTSMIN KMSLTLSRTS 
241:	SIVMLIAYIA YLIFQLWTHR QLFEAQQDDD DAYDDEVSVE ETPVIGFWSG FAWLVGMTIV 
301:	IALLSEYVVD TIEDASDSWG LSVSFISIIL LPIVGNAAEH AGAIIFAFKN KLDISLGVAL 
361:	GSATQISLFV VPLSVIVAWI LGIKMDLNFN ILETSSLALA IIITAFTLQD GTSHYMKGLV 
421:	LLLCYVIIAA CFFVDQIPQP NDLDVGLQPM NNLGEVFSA