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2.A.19.3.2
Probable Ca2+:3Na+ antiporter, Calx (contains two repeat motifs Calx-α and Calxβ, between the two transmembrane domains, as is true of many Ca2+:Na+ antiporters (Schwarz and Benzer, 1997). CALX activity is inhibited by Ca2+ interaction within its two intracellular Ca2+ regulatory domains CBD1 and CBD2. The Ca2+ inhibition of CALX is achieved by interdomain conformational changes induced by Ca2+ binding at CBD1 (Wu et al., 2011).

Accession Number:O18367
Protein Name:Na/Ca-exchange protein isoform A aka CalX
Length:950
Molecular Weight:106047.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+, Na+

Cross database links:

eggNOG: inNOG06140
Pfam: PF03160    PF01699   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005432 F:calcium:sodium antiporter activity
GO:0006816 P:calcium ion transport
GO:0007154 P:cell communication
GO:0007602 P:phototransduction
GO:0055085 P:transmembrane transport

References (1)

[1] “Anomalous regulation of the Drosophila Na(+)-Ca2+ exchanger by Ca2+.”  Hryshko L.V.et.al.   8817385

External Searches:

  • Search: DB with
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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQLLLKSIFT CALFVIFVYA TAQSLLKVQE TEARQAYLNV TSSSSSNLSQ DDGHFLSRRL 
61:	RQVSHGEEGD EGAPSQMDDE LEQMTKVHGE APDAEDVREC SEGLVLPLWM PQRNISVGDR 
121:	LVRGFVYFVL LIYLFVGVSI IADRFMAAIE AITSIERAVV VKGPNNTKQV MHVRIWNETV 
181:	ANLTLMALGS SAPEILLSVI EIYAKDFESG DLGPGTIVGS AAYNLFMIIA VCMIWIPAGE 
241:	VRRIRHLRVF FVTALFSVFA YVWLWLILSV FTPGVILVWE AIVTLLFFPL TVLWAYIAER 
301:	RLLVYKYMDK NYRVNKRGTV VAGEHDQVEM DAEKGPKQPM VTSARGNDAE AFDEARREYI 
361:	TLLTELRQKY PDADLEQLEM MAQEQVLARS GRSRAFYRIQ ATRKMVGSGN LMRKIQERAH 
421:	SDLTGVKAQL HAGDDEEADD PIRMYFEPGH YTVMENCGEF EVRVVRRGDI STYASVEYET 
481:	QDGTASAGTD FVGRKGLLSF PPGVDEQRFR IEVIDDDVFE EDECFYIRLF NPSEGVKLAV 
541:	PMIATVMILD DDHAGIFAFT DSVFEITESV GRFELKVMRY SGARGTVIVP YWTENDTATE 
601:	SKDYEGARGE LVFENNESEK FIDLFILEES SYEKDVSFKV HIGEPRLAPD DELAAKIKEV 
661:	EKKPVQDLTE LDRILLLSKP RNGELTTAYV RIRESQEFKA TVDKLVAKAN VSAVLGTSSW 
721:	KEQFKDALTV IPADESEFDN DDEEEEVPSC FSYVSHFVCL FWKVLFAFVP PTDICGGYVT 
781:	FVVSIFVIGV ITAIIGDAAS YFGCALNIKD SVTAILFVAL GTSIPDTFAS MIAAKHDEGA 
841:	DNCIGNVTGS NAVNVFLGIG LAWTIAAVYH SSHGMTFNVE PGTIGFAVAL FCGEALIAIM 
901:	LIMFRRWHKG IGAELGGPKV SKYISAAILV FLWVFYVVIC ILEAYDVIRV