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2.A.19.3.3
Plasma membrane sodium:calcium exchanger, NCX3, NAC3 or SLC8A3, controlling Ca2+ homeostasis. Extrudes 1 Ca2+ for 3 extracellular Na+ ions.  Potent inhibitors have been identified (Secondo et al. 2015). One such inhibitor of NCX transporters, ORM-10962, exhibits high efficacy and selectivity.  Selective NCX inhibition can exert positive as well as negative inotropic effects, depending on the actual operation mode of the NCX (Kohajda et al. 2016).

Accession Number:P57103
Protein Name:Sodium/calcium exchanger 3
Length:927
Molecular Weight:103010.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+, Na+

Cross database links:

Genevestigator: P57103 P57103
eggNOG: prNOG06898 NOG241889
HEGENOM: HBG755363 HOG000266971
RefSeq: NP_001123889.1    NP_150287.1    NP_891977.1    NP_891981.1    NP_892114.1   
Entrez Gene ID: 6547   
Pfam: PF03160    PF01699   
OMIM: 607991  gene
KEGG: hsa:6547    hsa:6547   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005432 F:calcium:sodium antiporter activity
GO:0005516 F:calmodulin binding
GO:0006816 P:calcium ion transport
GO:0007154 P:cell communication
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport
GO:0043197 C:dendritic spine
GO:0005874 C:microtubule
GO:0005739 C:mitochondrion
GO:0043025 C:neuronal cell body
GO:0005886 C:plasma membrane
GO:0042383 C:sarcolemma
GO:0007596 P:blood coagulation
GO:0060402 P:calcium ion transport into cytosol
GO:0071320 P:cellular response to cAMP
GO:0006811 P:ion transport
GO:0021537 P:telencephalon development

References (9)

[1] “The human SLC8A3 gene and the tissue-specific Na+/Ca2+ exchanger 3 isoforms.”  Gabellini N.et.al.   12406570
[2] “Control of the Na+/Ca2+ exchanger 3 promoter by cyclic adenosine monophosphate and Ca2+ in differentiating neurons.”  Gabellini N.et.al.   12558991
[3] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974
[4] “The human SLC8A3 gene and the tissue-specific Na+/Ca2+ exchanger 3 isoforms.”  Gabellini N.et.al.   12406570
[5] “Control of the Na+/Ca2+ exchanger 3 promoter by cyclic adenosine monophosphate and Ca2+ in differentiating neurons.”  Gabellini N.et.al.   12558991
[6] “Molecular cloning and characterization of two novel truncated isoforms of human Na+/Ca2+ exchanger 3, expressed in fetal brain.”  Lindgren R.M.et.al.   15777725
[7] “The DNA sequence and analysis of human chromosome 14.”  Heilig R.et.al.   12508121
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAWLRLQPLT SAFLHFGLVT FVLFLNGLRA EAGGSGDVPS TGQNNESCSG SSDCKEGVIL 
61:	PIWYPENPSL GDKIARVIVY FVALIYMFLG VSIIADRFMA SIEVITSQER EVTIKKPNGE 
121:	TSTTTIRVWN ETVSNLTLMA LGSSAPEILL SLIEVCGHGF IAGDLGPSTI VGSAAFNMFI 
181:	IIGICVYVIP DGETRKIKHL RVFFITAAWS IFAYIWLYMI LAVFSPGVVQ VWEGLLTLFF 
241:	FPVCVLLAWV ADKRLLFYKY MHKKYRTDKH RGIIIETEGD HPKGIEMDGK MMNSHFLDGN 
301:	LVPLEGKEVD ESRREMIRIL KDLKQKHPEK DLDQLVEMAN YYALSHQQKS RAFYRIQATR 
361:	MMTGAGNILK KHAAEQAKKA SSMSEVHTDE PEDFISKVFF DPCSYQCLEN CGAVLLTVVR 
421:	KGGDMSKTMY VDYKTEDGSA NAGADYEFTE GTVVLKPGET QKEFSVGIID DDIFEEDEHF 
481:	FVRLSNVRIE EEQPEEGMPP AIFNSLPLPR AVLASPCVAT VTILDDDHAG IFTFECDTIH 
541:	VSESIGVMEV KVLRTSGARG TVIVPFRTVE GTAKGGGEDF EDTYGELEFK NDETVKTIRV 
601:	KIVDEEEYER QENFFIALGE PKWMERGISA LLLSPDVTDR KLTMEEEEAK RIAEMGKPVL 
661:	GEHPKLEVII EESYEFKTTV DKLIKKTNLA LVVGTHSWRD QFMEAITVSA AGDEDEDESG 
721:	EERLPSCFDY VMHFLTVFWK VLFACVPPTE YCHGWACFAV SILIIGMLTA IIGDLASHFG 
781:	CTIGLKDSVT AVVFVAFGTS VPDTFASKAA ALQDVYADAS IGNVTGSNAV NVFLGIGLAW 
841:	SVAAIYWALQ GQEFHVSAGT LAFSVTLFTI FAFVCISVLL YRRRPHLGGE LGGPRGCKLA 
901:	TTWLFVSLWL LYILFATLEA YCYIKGF