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2.A.19.4.1
Rod photoreceptor Ca2+ + K+:4 Na+ antiporter, NCKX1

Accession Number:Q28139
Protein Name:SLC24A1 aka NCKX1
Length:1216
Molecular Weight:131614.00
Species:Bos taurus (Bovine) [9913]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+, K+, Na+

Cross database links:

eggNOG: maNOG12814
RefSeq: NP_777080.1   
Entrez Gene ID: 282474   
Pfam: PF01699   
KEGG: bta:282474   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0008273 F:calcium, potassium:sodium antiporter activity
GO:0015293 F:symporter activity
GO:0006816 P:calcium ion transport
GO:0006813 P:potassium ion transport
GO:0050896 P:response to stimulus
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport
GO:0007601 P:visual perception

References (3)

[1] “Primary structure and functional expression of the Na/Ca,K-exchanger from bovine rod photoreceptors.”  Reilaender H.et.al.   1582405
[2] “cDNA cloning of the human retinal rod Na-Ca + K exchanger: comparison with a revised bovine sequence.”  Tucker J.E.et.al.   9478004
[3] “The retinal rod Na(+)/Ca(2+),K(+) exchanger contains a noncleaved signal sequence required for translocation of the N-terminus.”  McKiernan C.J.et.al.   10608890

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MGKLIRMGAQ ERRSLWPKRL HWSRPLFLLG MLIIGSTYQY LTSPQGLPTL WAAVSSQHPV 
61:	KVASRDLSNK EMMMVSSETS KSSSEMEVEA WAPEATAGRD GTPPGIARKN TPSTPRGTAS 
121:	ITPAIPNNYS PTPTGTGKVK EDTSATPSGV LNHYTQSRPM VNSYTRLTAR GEVKSSRPTQ 
181:	SRGKEEKYSP SPLGRMVNSY APSTLMTMPR SHGITPRTTV KDREIMATKK MLATNPSKRL 
241:	VEKTTPTPLK GITDNTPTFL LSDLETDTLT SPRNVVEKKT LTTPRRVDSN SSTNHQGLVG 
301:	KNNLTTPQGM VLEHTAAVSE GQVTISTMTR SSPTETKAST DAWKVRNPLP RTSAPIIRIS 
361:	SATFRGLLKN PSKAPSTPAA PRVRANPTIQ VRHCLVVEPA PVAPTAPSPS WTTAVIPGIP 
421:	SPSGQPDLYP KAEYPRDLFS VEERRQGWVV LHIFGMMYVF VALAIVCDEY FVPALGVITD 
481:	KLQISEDVAG ATFMAAGGSA PELFTSLIGV FISHSNVGIG TIVGSAVFNI LFVIGTCALF 
541:	SREILNLTWW PLFRDITFYI FDLMMLILFF LDSLIAWWES VLLLLAYAFY VFTMKWNQQL 
601:	ELWVKEQLNK RPVAKVMALG DLSKPGDGTV VVDEQQDNKK LKLSSMLTRG SSSASLHNST 
661:	IRSTIYQLML HSLDPLGEAR PSKDKEEETL IPEAKATPQA KAESKPEEEP AKLPEVTVTP 
721:	APAPDVKGDQ EEDPGSQGVG AEAENTGERT GGEAEAPAEG ENGERSGGDA ALGGESEGKA 
781:	ENESEGDIPA ERRGDDEDEG EIQAEGGEVK GDEDEGEIQA GEGGEVEGDE DEGEIQAGEG 
841:	GEVEGDEDEG EIQAGEAGEV EGDEDEGEIQ AGEGGEVEGD EDEGEIQAGE AGEVEGDEDE 
901:	GEIQAGEGGE VKGDEGEIQA GEAGEVEGED GEVEGGEDEG EIQAGEGGEG ETGEQELNAE 
961:	IQGEAKDDEE GVDGEGGGDG GDSEDEEEED EEEEDEEEEE EEEEEEEEEN EQPLSLEWPE 
1021:	TRRKQAIYLF LLPIVFPLWL TVPDVRRLEA KKFFVITFLG SILWIAMFSY LMVWWAHQVG 
1081:	ETIGISEEIM GLTILAAGTS IPDLITSVIV ARKGLGDMAV SSSVGSNIFD ITVGLPLPWM 
1141:	LFSLINGLQP VAVSSNGLFC AIVLLFLMLL FVISSIALCK WRMNKILGFT MFLLYFVFLI 
1201:	ISVMLEDRII SCPVSV