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2.A.19.4.2
The major neuronal Ca2+ + K+:4 Na+ antiporter, NCKX2

Accession Number:O54701
Protein Name:NCKX2 aka SLC24A2
Length:670
Molecular Weight:74657.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+, K+, Na+

Cross database links:

Genevestigator: O54701
eggNOG: roNOG10569
RefSeq: NP_113931.1   
Entrez Gene ID: 84550   
Pfam: PF01699   
KEGG: rno:84550   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0008273 F:calcium, potassium:sodium antiporter activity
GO:0046983 F:protein dimerization activity
GO:0015293 F:symporter activity
GO:0006816 P:calcium ion transport
GO:0006813 P:potassium ion transport
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport
GO:0007601 P:visual perception

References (1)

[1] “Molecular cloning of a novel potassium-dependent sodium-calcium exchanger from rat brain.”  Tsoi M.et.al.   9461611

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MDLHQSATVR LLQEWCSHES PSGCRRHYNT RKKLKLIRVI GLVMGLVAVS TVPFSISAFT 
61:	ETYSQNNRGE ASDVTGPRAA PGHRQRTLLD LNDKIRDYTP QPPASQEDRS ENGTDHAQGD 
121:	YPKDVFSLEE RRKGAIILHV IGMIYMFIAL AIVCDEFFVP SLTVITEKLG ISDDVAGATF 
181:	MAAGGSAPEL FTSLIGVFIA HSNVGIGTIV GSAVFNILFV IGMCALFSRE ILNLTWWPLF 
241:	RDVSFYIVDL IMLIIFFLDN VIMWWESLLL LTAYFAYVVF MKFNVQVERW VKQMINRNKV 
301:	VKVTVSEAQA KASTAGDKEE PTLPNKPRLQ RGGSSASLHN SLMRNSIFQL MIHTLDPLAE 
361:	ELGSYGKLKY YDTMTEEGRF REKASILHKI AKKKCQVDEN ERQNGAANHV DYAAEKIELP 
421:	NSTSTEVEMT PSSEASEPVQ NGNLSHSIEA ADAPQATETA EEDDDQPLSL SWPSNTRKQI 
481:	TFLIVLPIVF PLWITLPDVR KPASKKFFPI TFFGSITWIA VFSYLMVWWA HQVGETIGIS 
541:	EEIMGLTILA AGTSIPDLIT SVIVARKGLG DMAVSSSVGS NIFDITVGLP LPWLLYTIIH 
601:	RFKPVTVSSN GLFCAIVLLF IMLIFVILSI ALCKWRMNKI LGFIMFGLYF AFLVVSVLLE 
661:	DKVLECPVSI