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2.A.19.4.6
Trans-Golgi network K+-dependent Na+/Ca2+ antiporter SLC24A5 (NCKX5) (regulates melanogenesis; determines skin color variation) (Ginger et al., 2008).

Accession Number:Q71RS6
Protein Name:NCKX5
Length:500
Molecular Weight:54888.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+, K+, Na+

Cross database links:

Genevestigator: Q71RS6 Q71RS6
eggNOG: prNOG11572 COG0530
HEGENOM: HBG444187 HOG000231933
RefSeq: NP_995322.1   
Entrez Gene ID: 283652   
Pfam: PF01699   
OMIM: 113750  phenotype
609802  gene
KEGG: hsa:283652    hsa:283652   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0042470 C:melanosome
GO:0015297 F:antiporter activity
GO:0015293 F:symporter activity
GO:0006816 P:calcium ion transport
GO:0006813 P:potassium ion transport
GO:0050896 P:response to stimulus
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport
GO:0005886 C:plasma membrane
GO:0006811 P:ion transport

References (8)

[1] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[2] “SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans.”  Lamason R.L.et.al.   16357253
[3] “Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.”  Chi A.et.al.   17081065
[4] “A genomewide association study of skin pigmentation in a South Asian population.”  Stokowski R.P.et.al.   17999355
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans.”  Lamason R.L.et.al.   16357253
[7] “Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.”  Chi A.et.al.   17081065
[8] “A genomewide association study of skin pigmentation in a South Asian population.”  Stokowski R.P.et.al.   17999355

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQTKGGQTWA RRALLLGILW ATAHLPLSGT SLPQRLPRAT GNSTQCVISP SSEFPEGFFT 
61:	RQERRDGGII IYFLIIVYMF MAISIVCDEY FLPSLEIISE SLGLSQDVAG TTFMAAGSSA 
121:	PELVTAFLGV FITKGDIGIS TILGSAIYNL LGICAACGLL SNTVSTLSCW PLFRDCAAYT 
181:	ISAAAVLGII YDNQVYWYEG ALLLLIYGLY VLVLCFDIKI NQYIIKKCSP CCACLAKAME 
241:	RSEQQPLMGW EDEGQPFIRR QSRTDSGIFY EDSGYSQLSI SLHGLSQVSE DPPSVFNMPE 
301:	ADLKRIFWVL SLPIITLLFL TTPDCRKKFW KNYFVITFFM SAIWISAFTY ILVWMVTITG 
361:	ETLEIPDTVM GLTLLAAGTS IPDTIASVLV ARKGKGDMAM SNIVGSNVFD MLCLGIPWFI 
421:	KTAFINGSAP AEVNSRGLTY ITISLNISII FLFLAVHFNG WKLDRKLGIV CLLSYLGLAT 
481:	LSVLYELGII GNNKIRGCGG