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2.A.19.4.7
The endomembrane Ca2+:cation exchanger (CCX, CAX9 or CCX3); transports H+, Na+, K+ and Mn2+; expressed primarily in flowers (Morris et al., 2008).

Accession Number:Q9LJI2
Protein Name:Na/Ca,K-exchanger-like protein
Length:643
Molecular Weight:70157.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate Ca2+, H+, Na+, K+, Mn2+

Cross database links:

Genevestigator: Q9LJI2
eggNOG: KOG2399
HEGENOM: HBG595493
RefSeq: NP_566474.1   
Entrez Gene ID: 820622   
Pfam: PF01699   
KEGG: ath:AT3G14070   

Gene Ontology

GO:0030659 C:cytoplasmic vesicle membrane
GO:0010008 C:endosome membrane
GO:0016021 C:integral to membrane
GO:0005774 C:vacuolar membrane
GO:0015297 F:antiporter activity
GO:0005384 F:manganese ion transmembrane transporter act...
GO:0015079 F:potassium ion transmembrane transporter act...
GO:0015081 F:sodium ion transmembrane transporter activity
GO:0030003 P:cellular cation homeostasis
GO:0043157 P:response to cation stress
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones.”  Kaneko T.et.al.   10907853
[2] “AtCCX3 is an Arabidopsis endomembrane H+ -dependent K+ transporter.”  Morris J.et.al.   18775974

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSAVSFLYSS KTPKFRGVFN GICALVLFCF FFDRSELLRN PLLRNASFVN GGSGSTSGGI 
61:	TQFMVIRRNA RQIETNGSGN NSSLSSSSTV LCSGLHKHMG YADQCEFLKA NPICSPDGFF 
121:	DYLSFFYCSC RDFSILGYMM LGVWLVALFY LLGNTAADYF CCSLEKLSKL LRLPPTVAGV 
181:	TLLPLGNGAP DVFASIAAFV GTDKGEVGLN SVLGGAVFVT SVVVGIVSLC VADKEVKIDK 
241:	NCFIRDLSFF LFSLVSLLVI LMVGRVTVRI AIAFVSIYVV YAFLVAANVI LRKHAKRFKL 
301:	EALTPLLPMQ GSVFSPSVGE DMPMNTPLIE TETEDGPPRL QSLPQWMWAS NVAIYSNHFA 
361:	KVSVHDEDRP PWGWIDDTAE VESSSCTKFT SLLEIPLTIP RRLTIPSVEE DTWSKTYAVA 
421:	SVSLAPVLLA SLWSSQDDVS LQACGVAYFF SVVIGSTLGF LAYKNTEPDH PPRRFLIPWV 
481:	LGGFIMSIVW FYMIANELVA LLVTFGEIYG INPSILALTV LAWGNSMGDL VSNIALTMNG 
541:	GDGVQIALSG CYAGPMFNTL VGLGMSMLFG AWSKSPDTYM LPEDKSLFYT LGFLVLGLVW 
601:	AMVILPRNDM QPSRTLGVGL IAIYLIFVTF RLSCAMGFIP WAA