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2.A.19.4.9
Na+/K+/Ca2+ exchanger-1 isoform 1, NCKX-1

Accession Number:O60721
Protein Name:Sodium/potassium/calcium exchanger 1
Length:1099
Molecular Weight:121374.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+, K+, Na+

Cross database links:

Genevestigator: O60721 O60721
eggNOG: COG0530 COG0530
HEGENOM: HOG000231933 HOG000231933
Entrez Gene ID: 9187   
Pfam: PF01699   
KEGG: hsa:9187    hsa:9187   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0019867 C:outer membrane
GO:0008273 F:calcium, potassium:sodium antiporter activity
GO:0005515 F:protein binding
GO:0015293 F:symporter activity
GO:0009642 P:response to light intensity
GO:0007601 P:visual perception

References (10)

[1] “Chromosomal localization and genomic organization of the human retinal rod Na-Ca+K exchanger.”  Tucker J.E.et.al.   9856482
[2] “cDNA cloning of the human retinal rod Na-Ca + K exchanger: comparison with a revised bovine sequence.”  Tucker J.E.et.al.   9478004
[3] “Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.”  Ishikawa K.et.al.   9734811
[4] “The retinal rod Na(+)/Ca(2+),K(+) exchanger contains a noncleaved signal sequence required for translocation of the N-terminus.”  McKiernan C.J.et.al.   10608890
[5] “A mutation in SLC24A1 implicated in autosomal-recessive congenital stationary night blindness.”  Riazuddin S.A.et.al.   20850105
[6] “Chromosomal localization and genomic organization of the human retinal rod Na-Ca+K exchanger.”  Tucker J.E.et.al.   9856482
[7] “cDNA cloning of the human retinal rod Na-Ca + K exchanger: comparison with a revised bovine sequence.”  Tucker J.E.et.al.   9478004
[8] “Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.”  Ishikawa K.et.al.   9734811
[9] “The retinal rod Na(+)/Ca(2+),K(+) exchanger contains a noncleaved signal sequence required for translocation of the N-terminus.”  McKiernan C.J.et.al.   10608890
[10] “A mutation in SLC24A1 implicated in autosomal-recessive congenital stationary night blindness.”  Riazuddin S.A.et.al.   20850105

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MGKLIRMGPQ ERWLLRTKRL HWSRLLFLLG MLIIGSTYQH LRRPRGLSSL WAAVSSHQPI 
61:	KLASRDLSSE EMMMMSSSPS KPSSEMGGKM LVPQASVGSD EATLSMTVEN IPSMPKRTAK 
121:	MIPTTTKNNY SPTAAGTERR KEDTPTSSRT LTYYTSTSSR QIVKKYTPTP RGEMKSYSPT 
181:	QVREKVKYTP SPRGRRVGTY VPSTFMTMET SHAITPRTTV KDSDITATYK ILETNSLKRI 
241:	MEETTPTTLK GMFDSTPTFL THEVEANVLT SPRSVMEKNN LFPPRRVESN SSAHPWGLVG 
301:	KSNPKTPQGT VLLHTPATSE GQVTISTMTG SSPAETKAFT AAWSLRNPSP RTSVSAIKTA 
361:	PAIVWRLAKK PSTAPSTSTT PTVRAKLTMQ VHHCVVVKPT PAMLTTPSPS LTTALLPEEL 
421:	SPSPSVLPPS LPDLHPKGEY PPDLFSVEER RQGWVVLHVF GMMYVFVALA IVCDEYFVPA 
481:	LGVITDKLQI SEDVAGATFM AAGGSAPELF TSLIGVFISH SNVGIGTIVG SAVFNILFVI 
541:	GTCSLFSREI LNLTWWPLFR DVSFYILDLI MLILFFLDSL IAWWESLLLL LAYAFYVFTM 
601:	KWNKHIEVWV KEQLSRRPVA KVMALEDLSK PGDGAIAVDE LQDNKKLKLP SLLTRGSSST 
661:	SLHNSTIRST IYQLMLHSLD PLREVRLAKE KEEESLNQGA RAQPQAKAES KPEEEEPAKL 
721:	PAVTVTPAPV PDIKGDQKEN PGGQEDVAEA ESTGEMPGEE GETAGEGETE EKSGGETQPE 
781:	GEGETETQGK GEECEDENEA EGKGDNEGED EGEIHAEDGE MKGNEGETES QELSAENHGE 
841:	AKNDEKGVED GGGSDGGDSE EEEEEEEEQE EEEEEEEQEE EEEEEEEEEE KGNEEPLSLD 
901:	WPETRQKQAI YLFLLPIVFP LWLTVPDVRR QESRKFFVFT FLGSIMWIAM FSYLMVWWAH 
961:	QVGETIGISE EIMGLTILAA GTSIPDLITS VIVARKGLGD MAVSSSVGSN IFDITVGLPV 
1021:	PWLLFSLING LQPVPVSSNG LFCAIVLLFL MLLFVISSIA SCKWRMNKIL GFTMFLLYFV 
1081:	FLIISVMLED RIISCPVSV