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2.A.19.6.1
Vacuolar electrogenic Mg2+, Zn2+, Fe2+, and possibly Cd2+:H+ antiporter, MHX (found in the vascular cylinder; may control the partitioning of Mg2+ and Zn2+ between plant organs).  MHX porters are found only in plants and probably have 9 TMSs.  Their properties have been reviewed (Gaash et al. 2013).

Accession Number:O22252
Protein Name:Putative Na+/Ca2+ antiporter aka AtMHX
Length:539
Molecular Weight:59792.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Mg2+, Zn2+, Fe2+, Cd2+, H+

Cross database links:

Genevestigator: O22252
eggNOG: KOG1306
HEGENOM: HBG319530
RefSeq: NP_566105.1   
Entrez Gene ID: 819373   
Pfam: PF01699   
KEGG: ath:AT2G47600   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0006826 P:iron ion transport
GO:0015693 P:magnesium ion transport
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport

References (2)

[1] “Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.”  Lin X.et.al.   10617197
[2] “Cloning and characterization of a novel Mg(2+)/H(+) exchanger.”  Shaul O.et.al.   10406802

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MASILNQTQE LQESSKVLGH LRCENFFLFP GENTLSDGLR GVLYFLGLAY CFIGLSAITA 
61:	RFFKSMENVV KHSRKVVTID PITKAEVITY KKVWNFTIAD ISLLAFGTSF PQISLATIDA 
121:	IRNMGERYAG GLGPGTLVGS AAFDLFPIHA VCVVVPKAGE LKKISDLGVW LVELVWSFWA 
181:	YIWLYIILEV WSPNVITLVE ALLTVLQYGL LLVHAYAQDK RWPYLSLPMS RGDRPEEWVP 
241:	EEIDTSKDDN DNDVHDVYSD AAQDAVESGS RNIVDIFSIH SANNDTGITY HTVADTPPDS 
301:	ATKKGKAKNS TVFDIWKHQF VDAITLETSE SKKVDSIYLR IAKSFWHLLL APWKLLFAFV 
361:	PPCNIAHGWI AFICSLLFIS GVAFVVTRFT DLISCVTGIN PYVIAFTALA SGTSWPDLVA 
421:	SKIAAERQLT ADSAIANITC SNSVNIYVGI GVPWLINTVY NYFAYREPLY IENAKGLSFS 
481:	LLIFFATSVG CIVVLVLRRL IIGAELGGPR LWAWLTSAYF MMLWVVFVVL SSLKVSGVI