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2.A.19.8.1
Calcium:proton exchanger, CAX(CK31).  The function was demonstrated by purification and reconstitution in liposomes (Ridilla et al. 2012).  The protein forms dimers in the membrane but can be purified as a monomer.  The dimer interface seems to involve TMSs 2 and 6 (Ridilla et al. 2012).

Accession Number:B0SUU5
Protein Name:Sodium/calcium exchanger membrane region
Length:440
Molecular Weight:46849.00
Species:Caulobacter sp. (strain K31) [366602]
Number of TMSs:14
Substrate Ca2+, H+

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSLSSSQARQ LWIPVGLAVA VMLPALALRI AGWRPNPVLD IGVFGAAILA AGFLLSWGAE 
61:	AAEKYLSQGL ILAAVALVTV LPEYAVDIYY AFQAGRSPSE GYVAFAAANM TGANRLLIGL 
121:	AWPAMVLLHW WKNRQRGIEL APVNAIEIVV LALSSAYAFV IILKNTISAW DAVVLVGLFG 
181:	LYLWRVSKLP KAQDEDEGEE PGPGAVIAKL SNTTRWTVMI AMTVVAAGVI LVVAEPFAES 
241:	MIDGGRALGI DQFLLIQWLA PIASEAPAVV IAVLFVLAGR AAAGLVAMIS DKINQWTLLV 
301:	GMLPLAMSLG AGQLRALPLD ARQHEEFFLT AAQSLFGLAL LLRLRLSVIG AIALLGLFVA 
361:	QLMIALSLRQ DEARDIAALT AVAWGYLVLA GLLFALNWRA IAGLLSTAFS LTANLETVAD 
421:	PHLARPTPSP ERARDDAQEH