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2.A.19.8.2
Ca2+:H+ antiporter of 405 aas, CAX_Af.  The inward facing 3-d structure has been solved to 2.3 Å resolution (Nishizawa et al. 2013).  The authors compare this structure to the outward facing 1.9 Å structure of NCX_Mj (TC# 2.A.19.5.3) and suggest that Ca2+ or H+ binds to the cation-binding site mutually exclusively.  The first and sixth TMSs alternately create hydrophilic cavities on the intra- and extracellluar sides of the membrane.  The inward and outward-facing transitions are triggered by ion binding (Nishizawa et al. 2013).

Accession Number:O29988
Protein Name:Putative uncharacterized protein
Length:394
Molecular Weight:43713.00
Species:Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [224325]
Number of TMSs:12
Substrate Ca2+, H+

Cross database links:

Structure:
4KPP     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDFTKEKFQL LAISSLTLPW LISLAFNYHH PALTQTLLSG LAVVSASFLI SWAAETAEMD 
61:	VPRSFSLAIV ALLAVLPEYA VDGYFAWKAG SVGGEYVHYA TANMTGANRL LIGIGWSLVA 
121:	FIAFRTLKSK EVELDDGIRL EIFFLFLATL YAFTLPLKGH ISPFDALVFV SLYAIYIYLS 
181:	TKAEREEVEV GGVPAYLCSL KTETRRLSVV VLFLFAGFTI LMSVEAFSEG LLETARIAGI 
241:	DEFLAVQWIA PLASESPELI VAIYFVRRFR VSASMNALIS SKVNQWTLLI GTIAIIYSIS 
301:	AFKLQSLPLD ARQSEEVLLT AAQSLFAVAI LLDLKISWKE ASALFLLFIV QLLFPGVEVR 
361:	YIISAIYIIL SLPILFAKRK EIVESFRTVK RLIS