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2.A.2.2.1
Lactose permease, LacS. Mediates uptake of β-galactooligosaccharides, lactitol, and a broad range of prebiotic β-galactosides that selectively stimulate beneficial gut microbiota (Andersen et al., 2011). 

Accession Number:P23936
Protein Name:LACY aka LacS
Length:634
Molecular Weight:69454.00
Species:Streptococcus thermophilus [1308]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Lactitol, Beta-galactooligosaccharides, Lactose

Cross database links:

Pfam: PF00358   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0016301 F:kinase activity
GO:0005351 F:sugar:hydrogen symporter activity
GO:0009401 P:phosphoenolpyruvate-dependent sugar phospho...
GO:0006814 P:sodium ion transport

References (2)

[1] “Lactose transport system of Streptococcus thermophilus: a hybrid protein with homology to the melibiose carrier and enzyme III of phosphoenolpyruvate-dependent phosphotransferase systems.”  Poolman B.et.al.   2644191
[2] “Carbohydrate utilization in Streptococcus thermophilus: characterization of the genes for aldose 1-epimerase (mutarotase) and UDPglucose 4-epimerase.”  Poolman B.et.al.   1694527

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEKSKGQMKS RLSYAAGAFG NDVFYATLST YFIMFVTTHL FNTGDPKQNS HYVLLITNII 
61:	SILRILEVFI DPLIGNMIDN TNTKYGKFKP WVVGGGIISS ITLLLLFTDL GGLNKTNPFL 
121:	YLVLFGIIYL VMDVFYSIKD IGFWSMIPAL SLDSHEREKM ATFARIGSTI GANIVGVAIM 
181:	PIVLFFSMTN NSGSGDKSGW FWFAFIVALI GVITSIAVGI GTREVESKIR DNNEKTSLKQ 
241:	VFKVLGQNDQ LMWLSLGYWF YGLGINTLNA LQLYYFTFIL GDSGKYSILY GLNTVVGLVS 
301:	VSLFPTLADK FNRKRLFYGC IAVMLGGIGI FSIAGTSLPI ILTAAELFFI PQPLVFLVVF 
361:	MIISDSVEYG QWKTGHRDES LTLSVRPLID KLGGAMSNWL VSTFAVAAGM TTGASASTIT 
421:	THQQFIFKLG MFAFPAATML IGAFIVARKI TLTEARHAKI VEELEHRFSV ATSENEVKAN 
481:	VVSLVTPTTG YLVDLSSVND EHFASGSMGK GFAIKPTDGA VFAPISGTIR QILPTRHAVG 
541:	IESEDGVIVL IHVGIGTVKL NGEGFISYVE QGDRVEVGQK LLEFWSPIIE KNGLDDTVLV 
601:	TVTNSEKFSA FHLEQKVGEK VEALSEVITF KKGE