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2.A.2.4.4
The brain proton:associated sugar (glucose) transporter, PAST-A (Shimokawa et al., 2002)

Accession Number:Q8K4S3
Protein Name:Proton-associated sugar transporter A aka PAST-A
Length:751
Molecular Weight:81752.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate glucose

Cross database links:

Genevestigator: Q8K4S3
Pfam: PF07690   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005355 F:glucose transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0015758 P:glucose transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Past-A, a novel proton-associated sugar transporter, regulates glucose homeostasis in the brain.”  Shimokawa N.et.al.   12417639

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MIPPAGSTPP GEALIPSVAP QDFWRSPISG YSGSVTRHIS HRANNFKRHP KRRKYIRPSP 
61:	PPPPNTPCPI ELVDFEDLHP QRSFWELLFN GCILFGIEFS YAMETAYVTP VLLQMGLPDQ 
121:	LYSLVWFISP ILGFLLQPLL GAWSDRCTSR FGRRRPFILV LAIGALLGLS LLLNGRDIGM 
181:	ALADTATNHK WGILLTVCGV VLMDFSADSA DNPSHAYMMD VCGPVDQDRG LNIHALMAGL 
241:	GGGFGYVVGG IHWDKTSFGR ALGGQLRVIY IFTAITLSVT TVFTLVSIPE RPLRPLGEKR 
301:	TAMKSPSLPL PPSPPVLLEE GAGDTLPSTT ATSLYASFSS PISPPSPLTP KYGSFISRDS 
361:	SLTGINEFAS SFGTSNIDSV LIDCFTAGHD NYLALPSSVP RQAISVSFPR APDGFYCQER 
421:	GLERREGPLT LGLDGDVLRV GSLDTSKPRA SGILKRPQTL ALPDVAGGNG PETSRRRNVT 
481:	FSQQVANILL NGVKYESELT GSSEQSEQPL SLRRLCSTIY NMPRPVRNLC VNHFLGWLSF 
541:	EGMLLFYTDF MGEVVFQGDP KAPHASEAYQ KYNSGVTMGC WGMCIYAFSA AFYSAILEKL 
601:	EECLSVRTLY FIAYLLFGLG TGLATLSRNL YVVLSLCTHY GILFSTLCTL PYSLLCDYYQ 
661:	SKKFAGSSAD GTRRGMGVDI SLLSCQYFLA QILVSLVLGP LTSAVGSANG VMYFASLVSF 
721:	LGCLYSSLCV TYEIPSADAA DEERQPLLLN V