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2.A.2.4.8
solute carrier family 45, member 3, Slc45A3.  Sucrose:proton symporter associated with prostate cancer and myelination (Bartölke et al. 2014).

Accession Number:Q96JT2
Protein Name:Solute carrier family 45 member 3
Length:553
Molecular Weight:59323.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Sucrose

Cross database links:

Genevestigator: Q96JT2 Q96JT2
eggNOG: NOG331272 NOG331272
HEGENOM: HOG000013046 HOG000013046
Entrez Gene ID: 85414   
Pfam: PF07690   
KEGG: hsa:85414    hsa:85414   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0055085 P:transmembrane transport

References (6)

[1] “Identification and characterization of prostein, a novel prostate-specific protein.”  Xu J.et.al.   11245466
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Identification of an HLA-A(*)0201-restricted T-cell epitope derived from the prostate cancer-associated protein prostein.”  Kiessling A.et.al.   14997204
[4] “Identification and characterization of prostein, a novel prostate-specific protein.”  Xu J.et.al.   11245466
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Identification of an HLA-A(*)0201-restricted T-cell epitope derived from the prostate cancer-associated protein prostein.”  Kiessling A.et.al.   14997204

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVQRLWVSRL LRHRKAQLLL VNLLTFGLEV CLAAGITYVP PLLLEVGVEE KFMTMVLGIG 
61:	PVLGLVCVPL LGSASDHWRG RYGRRRPFIW ALSLGILLSL FLIPRAGWLA GLLCPDPRPL 
121:	ELALLILGVG LLDFCGQVCF TPLEALLSDL FRDPDHCRQA YSVYAFMISL GGCLGYLLPA 
181:	IDWDTSALAP YLGTQEECLF GLLTLIFLTC VAATLLVAEE AALGPTEPAE GLSAPSLSPH 
241:	CCPCRARLAF RNLGALLPRL HQLCCRMPRT LRRLFVAELC SWMALMTFTL FYTDFVGEGL 
301:	YQGVPRAEPG TEARRHYDEG VRMGSLGLFL QCAISLVFSL VMDRLVQRFG TRAVYLASVA 
361:	AFPVAAGATC LSHSVAVVTA SAALTGFTFS ALQILPYTLA SLYHREKQVF LPKYRGDTGG 
421:	ASSEDSLMTS FLPGPKPGAP FPNGHVGAGG SGLLPPPPAL CGASACDVSV RVVVGEPTEA 
481:	RVVPGRGICL DLAILDSAFL LSQVAPSLFM GSIVQLSQSV TAYMVSAAGL GLVAIYFATQ 
541:	VVFDKSDLAK YSA