TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.21.1.1
Pantothenate:Na+ symporter, PanF (Vallari and Rock 1985; Jackowski and Alix 1990; Reizer et al. 1991).

Accession Number:P16256
Protein Name:PANF aka PanF aka B3258
Length:483
Molecular Weight:51717.00
Species:Escherichia coli [83333]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Pantothenate

Cross database links:

Genevestigator: P16256
EchoBASE: EB0679
EcoGene: EG10685
eggNOG: COG4145
HEGENOM: HBG352968
DIP: DIP-10439N
RefSeq: AP_003798.1    NP_417724.4   
Entrez Gene ID: 947752   
Pfam: PF00474   
BioCyc: EcoCyc:PANF-MONOMER    ECOL168927:B3258-MONOMER   
KEGG: ecj:JW3226    eco:b3258   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015233 F:pantothenate transporter activity
GO:0031402 F:sodium ion binding
GO:0015081 F:sodium ion transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0015887 P:pantothenate transmembrane transport
GO:0006814 P:sodium ion transport

References (5)

[1] “Cloning, sequence, and expression of the pantothenate permease (panF) gene of Escherichia coli.”  Jackowski S.et.al.   2193919
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Cotranscription of two genes necessary for ribosomal protein L11 methylation (prmA) and pantothenate transport (panF) in Escherichia coli K-12.”  Vanet A.et.al.   8226664
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MQLEVILPLV AYLVVVFGIS VYAMRKRSTG TFLNEYFLGS RSMGGIVLAM TLTATYISAS 
61:	SFIGGPGAAY KYGLGWVLLA MIQLPAVWLS LGILGKKFAI LARRYNAVTL NDMLFARYQS 
121:	RLLVWLASLS LLVAFVGAMT VQFIGGARLL ETAAGIPYET GLLIFGISIA LYTAFGGFRA 
181:	SVLNDTMQGL VMLIGTVVLL IGVVHAAGGL SNAVQTLQTI DPQLVTPQGA DDILSPAFMT 
241:	SFWVLVCFGV IGLPHTAVRC ISYKDSKAVH RGIIIGTIVV AILMFGMHLA GALGRAVIPD 
301:	LTVPDLVIPT LMVKVLPPFA AGIFLAAPMA AIMSTINAQL LQSSATIIKD LYLNIRPDQM 
361:	QNETRLKRMS AVITLVLGAL LLLAAWKPPE MIIWLNLLAF GGLEAVFLWP LVLGLYWERA 
421:	NAKGALSAMI VGGVLYAVLA TLNIQYLGFH PIVPSLLLSL LAFLVGNRFG TSVPQATVLT 
481:	TDK