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2.A.21.2.2
Sodium/proline symporter (Proline permease)

Accession Number:Q7A4Q7
Protein Name:Sodium/proline symporter
Length:512
Molecular Weight:55976.00
Species:Staphylococcus aureus (strain N315) [158879]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+, Proline

Cross database links:

eggNOG: COG0591
HEGENOM: HOG000282935
Entrez Gene ID: 1124602   
Pfam: PF00474   
KEGG: sau:SA1718   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005298 F:proline:sodium symporter activity
GO:0031402 F:sodium ion binding

References (1)

[1] “Whole genome sequencing of meticillin-resistant Staphylococcus aureus.”  Kuroda M.et.al.   11418146

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MLTMGTALSQ QVDANWQTYI MIAVYFLILI VIGFYGYKQA TGNLSEYMLG GRSIGPYITA 
61:	LSAGASDMSG WMIMGLPGSV YSTGLSAMWI TIGLTLGAYI NYFVVAPRLR VYTELAGDAI 
121:	TLPDFFKNRL NDKNNVLKII SGLIIVVFFT LYTHSGFVSG GKLFESAFGL DYHFGLILVA 
181:	FIVIFYTFFG GYLAVSITDF FQGVIMLIAM VMVPIVAMMN LNGWGTFHDV AAMKPTNLNL 
241:	FKGLSFIGII SLFSWGLGYF GQPHIIVRFM SIKSHKMLPK ARRLGISWMA VGLLGAVAVG 
301:	LTGIAFVPAY HIKLEDPETL FIVMSQVLFH PLVGGFLLAA ILAAIMSTIS SQLLVTSSSL 
361:	TEDFYKLIRG EEKAKTHQKE FVMIGRLSVL VVAIVAIAIA WNPNDTILNL VGNAWAGFGA 
421:	SFSPLVLFAL YWKGLTRAGA VSGMVSGALV VIVWIAWIKP LAHINEIFGL YEIIPGFIVS 
481:	VIVTYVVSKL TKKPGAFVET DLNKVRDIVR EK