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2.A.21.3.14
Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3)

Accession Number:P53794
Protein Name:Sodium/myo-inositol cotransporter
Length:718
Molecular Weight:79694.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+, myo-inositol

Cross database links:

Genevestigator: P53794
eggNOG: COG4146
HEGENOM: HOG000025422
Entrez Gene ID: 6526   
Pfam: PF00474   
KEGG: hsa:6526   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005367 F:myo-inositol:sodium symporter activity
GO:0006020 P:inositol metabolic process
GO:0007422 P:peripheral nervous system development
GO:0043576 P:regulation of respiratory gaseous exchange

References (3)

[1] “The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21.”  Berry G.T.et.al.   7789985
[2] “The structural organization of the human Na+/myo-inositol cotransporter (SLC5A3) gene and characterization of the promoter.”  Mallee J.J.et.al.   9441750
[3] “The DNA sequence of human chromosome 21.”  Hattori M.et.al.   10830953

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRAVLDTADI AIVALYFILV MCIGFFAMWK SNRSTVSGYF LAGRSMTWVT IGASLFVSNI 
61:	GSEHFIGLAG SGAASGFAVG AWEFNALLLL QLLGWVFIPI YIRSGVYTMP EYLSKRFGGH 
121:	RIQVYFAALS LILYIFTKLS VDLYSGALFI QESLGWNLYV SVILLIGMTA LLTVTGGLVA 
181:	VIYTDTLQAL LMIIGALTLM IISIMEIGGF EEVKRRYMLA SPDVTSILLT YNLSNTNSCN 
241:	VSPKKEALKM LRNPTDEDVP WPGFILGQTP ASVWYWCADQ VIVQRVLAAK NIAHAKGSTL 
301:	MAGFLKLLPM FIIVVPGMIS RILFTDDIAC INPEHCMLVC GSRAGCSNIA YPRLVMKLVP 
361:	VGLRGLMMAV MIAALMSDLD SIFNSASTIF TLDVYKLIRK SASSRELMIV GRIFVAFMVV 
421:	ISIAWVPIIV EMQGGQMYLY IQEVADYLTP PVAALFLLAI FWKRCNEQGA FYGGMAGFVL 
481:	GAVRLILAFA YRAPECDQPD NRPGFIKDIH YMYVATGLFW VTGLITVIVS LLTPPPTKEQ 
541:	IRTTTFWSKK NLVVKENCSP KEEPYQMQEK SILRCSENNE TINHIIPNGK SEDSIKGLQP 
601:	EDVNLLVTCR EEGNPVASLG HSEAETPVDA YSNGQAALMG EKERKKETDD GGRYWKFIDW 
661:	FCGFKSKSLS KRSLRDLMEE EAVCLQMLEE TRQVKVILNI GLFAVCSLGI FMFVYFSL