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2.A.21.3.17
Sodium/glucose cotransporter 4 (Na+/glucose cotransporter 4) (hSGLT4) (Solute carrier family 5 member 9).  The involvement of aromatic residue pi interactions, especially with Na+ binding, has been examined (Jiang et al. 2012).

Accession Number:Q2M3M2
Protein Name:Sodium/glucose cotransporter 4
Length:681
Molecular Weight:74073.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate glucose, Na+

Cross database links:

Genevestigator: Q2M3M2
eggNOG: COG4146
HEGENOM: HOG000025422
Entrez Gene ID: 200010   
Pfam: PF00474   
KEGG: hsa:200010   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (3)

[1] “SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose.”  Tazawa S.et.al.   15607332
[2] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSKELAAMGP GASGDGVRTE TAPHIALDSR VGLHAYDISV VVIYFVFVIA VGIWSSIRAS 
61:	RGTIGGYFLA GRSMSWWPIG ASLMSSNVGS GLFIGLAGTG AAGGLAVGGF EWNATWLLLA 
121:	LGWVFVPVYI AAGVVTMPQY LKKRFGGQRI QVYMSVLSLI LYIFTKISTD IFSGALFIQM 
181:	ALGWNLYLST GILLVVTAVY TIAGGLMAVI YTDALQTVIM VGGALVLMFL GFQDVGWYPG 
241:	LEQRYRQAIP NVTVPNTTCH LPRPDAFHIL RDPVSGDIPW PGLIFGLTVL ATWCWCTDQV 
301:	IVQRSLSAKS LSHAKGGSVL GGYLKILPMF FIVMPGMISR ALFPDEVGCV DPDVCQRICG 
361:	ARVGCSNIAY PKLVMALMPV GLRGLMIAVI MAALMSSLTS IFNSSSTLFT IDVWQRFRRK 
421:	STEQELMVVG RVFVVFLVVI SILWIPIIQS SNSGQLFDYI QAVTSYLAPP ITALFLLAIF 
481:	CKRVTEPGAF WGLVFGLGVG LLRMILEFSY PAPACGEVDR RPAVLKDFHY LYFAILLCGL 
541:	TAIVIVIVSL CTTPIPEEQL TRLTWWTRNC PLSELEKEAH ESTPEISERP AGECPAGGGA 
601:	AENSSLGQEQ PEAPSRSWGK LLWSWFCGLS GTPEQALSPA EKAALEQKLT SIEEEPLWRH 
661:	VCNINAVLLL AINIFLWGYF A