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2.A.21.3.2
Glucose or galactose:Na+ symporter, SglS or SglT. The 3.0Å structure is known (Faham et al., 2008). Sodium exit causes a reorientation of transmembrane helix 1 that opens an inner gate required for substrate exit (Watanabe et al., 2010). The involvement of aromatic residue pi interactions, especially with Na+ binding, has been examined (Jiang et al. 2012).

Accession Number:P96169
Protein Name:SglS aka SGLT
Length:543
Molecular Weight:58875.00
Species:Vibrio parahaemolyticus [670]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate glucose, Galactose, Na+

Cross database links:

Pfam: PF00474   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015293 F:symporter activity
GO:0008643 P:carbohydrate transport
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (3)

[1] “Sequence of a Na+/glucose symporter gene and its flanking regions of Vibrio parahaemolyticus.”  Sarker R.I.et.al.   8652595
[2] “Molecular characterization of Vibrio parahaemolyticus vSGLT: a model for sodium-coupled sugar cotransporters.”  Turk E.et.al.   10835424
[3] “Proteomics on full-length membrane proteins using mass spectrometry.”  le Coutre J.et.al.   10757971
Structure:
3DH4   2XQ2     

External Searches:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSNIEHGLSF IDIMVFAIYV AIIIGVGLWV SRDKKGTQKS TEDYFLAGKS LPWWAVGASL 
61:	IAANISAEQF IGMSGSGYSI GLAIASYEWM SAITLIIVGK YFLPIFIEKG IYTIPEFVEK 
121:	RFNKKLKTIL AVFWISLYIF VNLTSVLYLG GLALETILGI PLMYSILGLA LFALVYSIYG 
181:	GLSAVVWTDV IQVFFLVLGG FMTTYMAVSF IGGTDGWFAG VSKMVDAAPG HFEMILDQSN 
241:	PQYMNLPGIA VLIGGLWVAN LYYWGFNQYI IQRTLAAKSV SEAQKGIVFA AFLKLIVPFL 
301:	VVLPGIAAYV ITSDPQLMAS LGDIAATNLP SAANADKAYP WLTQFLPVGV KGVVFAALAA 
361:	AIVSSLASML NSTATIFTMD IYKEYISPDS GDHKLVNVGR TAAVVALIIA CLIAPMLGGI 
421:	GQAFQYIQEY TGLVSPGILA VFLLGLFWKK TTSKGAIIGV VASIPFALFL KFMPLSMPFM 
481:	DQMLYTLLFT MVVIAFTSLS TSINDDDPKG ISVTSSMFVT DRSFNIAAYG IMIVLAVLYT 
541:	LFW