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2.A.21.3.22
Renal Na+:D-glucose symporter type 1 (Sglt1; Slc5a1) of 662 aas and 14 TMSs.  The distribution in renal tissues has been reported (Althoff et al. 2007). Loop 13, which is associated with phlorizin binding, is variable, as is the interaction with this inhibitor in various species. Immunoreaction was observed in the proximal tubular segments PIa and PIIa, the early distal tubule, and the collecting tubule. Thus, Leucoraja, in contrast to the mammalian kidney, employs only SGLT1 to reabsorb D-glucose in the early, as well as in the late segments of the proximal tubule and probably also in the late distal tubule. It differs from the kidney of the close relative, Squalus acanthias, which uses SGLT2 in more distal proximal tubular segments (Althoff et al. 2007).

Accession Number:Q2A687
Protein Name:Solute carrier family 5 (Sodium/glucose cotransporter), member 1
Length:662
Molecular Weight:73075.00
Species:Leucoraja erinacea (Little skate) [7782]
Number of TMSs:14
Substrate D-glucose

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDSSTVSASL STGPVPTPDG SVVVNNPADI SVIVIYFLLV LAVGIWAMVQ SNRGTVGGFF 
61:	LAGRSMSWWP IGASLFASNI GSGHFVGLAG NGAAGGLATG GFEWNALVIV IVLGWLFVPI 
121:	YIRAGVVTMP EYLKKRFGGN RIRIYLSVLS LFLYIFTKIS ADMFSGAIFI REALGLNIYV 
181:	AVVILLSITA LYTVTGGLAA VIYTDTLQTI IMVVGSFILM GYAFNAVGGY EAMREKYMNA 
241:	ITTQTFDPVL NISANCYTPR SDSFHLFRNP LTADLPWPGL IFGLSILAIW YWCTDQVIVQ 
301:	RCLSAKNMSH VKAGCVLCGY LKLLPMYLMV FPGMISRILY TDTIACVVPS LCKQYCDTEV 
361:	GCSNIAYPTL VVRLMPAGLR GLMLSVMLAS LMSSLTSIFN SASTLFTMDI WTKIRPKATE 
421:	KELMLAGRVF TLVLIAISIA WIPIVQTAQS GKLFDYIQSV TSYLGPPIAS VFLLGIFVKR 
481:	TNEKGAFWGL IFGLAMGLSR MIPEFVFGTG SCVRPSNCPL IICGIHYLYF AIILFVATCL 
541:	LVLIISLLTK PIEDKHLHRL CWTLRNSTEE REDLGFDDWK NEDTDSKTDV DEDEQQDLPC 
601:	WKKGYNWFCG FGQKAQKLSK EEEEILQKKL TDISEVPLWR NVVNINAIIL LSVCVFFWAF 
661:	YA