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2.A.21.3.4
Glucose:Na+ symporter 3 (low affinity)

Accession Number:P31636
Protein Name:SL54 aka SLC5A4 aka SGLT3 aka SAAT1
Length:660
Molecular Weight:72745.00
Species:Sus scrofa (Pig) [9823]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate glucose, Na+

Cross database links:

RefSeq: NP_999347.1   
Entrez Gene ID: 397376   
Pfam: PF00474   
KEGG: ssc:397376   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015293 F:symporter activity
GO:0008643 P:carbohydrate transport
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Cloning and expression of a mammalian Na+/amino acid cotransporter with sequence similarity to Na+/glucose cotransporters.”  Kong C.-T.et.al.   8420925
[2] “SAAT1 is a low affinity Na+/glucose cotransporter and not an amino acid transporter. A reinterpretation.”  McKenzie B.et.al.   8077195

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MASTLSPSTV TKTPGPPEIS ERIQNAADIS VIVIYFVVVM AVGLWAMLRT NRGTVGGFFL 
61:	AGRDVTWWPM GASLFASNIG SGHFVGLAGT GAASGIAIAA FEWNALLLLL VLGWFFVPIY 
121:	IKAGVMTMPE YLRKRFGGKR LQIYLSILSL FICVALRISS DIFSGAIFIK LALGLDLYLA 
181:	IFSLLAITAI YTITGGLASV IYTDTLQTII MLIGSFILMG FAFVEVGGYE SFTEKYMNAI 
241:	PTIVEGDNLT ISPKCYTPQG DSFHIFRDAV TGDIPWPGMI FGMTVVAAWY WCTDQVIVQR 
301:	CLSGKDMSHV KAACIMCGYL KLLPMFLMVM PGMISRILYT EKVACVVPSE CVKHCGTEVG 
361:	CSNYAYPLLV MELMPSGLRG LMLSVMLASL MSSLTSIFNS ASTLFTMDLY TKIRKQASEK 
421:	ELLIAGRLFI ILLIVISIVW VPLVQVAQNG QLFHYIESIS SYLGPPIAAV FLLAIFCKRV 
481:	NEQGAFWGLI IGFVMGLIRM IAEFVYGTGS CLAASNCPQI ICGVHYLYFA LILFFVSILV 
541:	VLAISLLTKP IPDVHLYRLC WALRNSTEER IDLDAEEKRH EEAHDGVDED NPEETRGCLR 
601:	KAYDLFCGLQ RKGPKLSKEE EEAQKRKLTD TSEKPLWKTI VNINAILLLA VAVFVHGYFA