TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.21.3.5
Myoinositol:Na+ symporter, SMIT1 (Aouameur et al., 2007).

Accession Number:P31637
Protein Name:SL53 aka SMIT aka SLC5A3
Length:718
Molecular Weight:79546.00
Species:Canis familiaris (Dog) [9615]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate myo-inositol, Na+

Cross database links:

eggNOG: maNOG05228
RefSeq: XP_535588.1   
Entrez Gene ID: 445542   
Pfam: PF00474   
KEGG: cfa:445542   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015293 F:symporter activity
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Cloning of the cDNA for a Na+/myo-inositol cotransporter, a hypertonicity stress protein.”  Kwon H.M.et.al.   1372904

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MRAVLETADI AIVALYFILV MCIGFFAMWK SNRSTVSGYF LAGRSMTWVA IGASLFVSNI 
61:	GSEHFIGLAG SGAASGFAVG AWEFNALLLL QLLGWVFIPI YIRSGVYTMP EYLSKRFGGH 
121:	RIQVYFAALS LILYIFTKLS VDLYSGALFI QESLGWNLYV SVILLIGMTA LLTVTGGLVA 
181:	VIYTDTLQAL LMIVGALTLM IISMMEIGGF EEVKRRYMLA SPNVTSILLT YNLSNTNSCN 
241:	VHPKKDALKM LRNPTDEDVP WPGFVLGQTP ASVWYWCADQ VIVQRVLAAK NIAHAKGSTL 
301:	MAGFLKLLPM FIIVVPGMIS RILFADDIAC INPEHCMQVC GSRAGCSNIA YPRLVMKLVP 
361:	VGLRGLMMAV MIAALMSDLD SIFNSASTIF TLDVYKLIRR SASSRELMIV GRIFVAFMVV 
421:	ISIAWVPIIV EMQGGQMYLY IQEVADYLTP PVAALFLLAI FWKRCNEQGA FYGGMAGFVL 
481:	GAVRLTLAFA YRAPECDQPD NRPGFIKDIH YMYVATALFW VTGLITVIVS LLTPPPTKEQ 
541:	IRTTTFWSKK SLVVKESCSP KDEPYKMQEK SILRCSENSE ATNHIIPNGK SEDSIKGLQP 
601:	EDVNLLVTCR EEGNPVASLG HSEAETPVDA YSNGQAALMG EKERKKETED GGRYWKFIDW 
661:	FCGFKSKSLS KRSLRDLMEE EAVCLQMLEE PPQVKLILNI GLFAVCSLGI FMFVYFSL