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2.A.21.3.6
Myoinositol:Na+ symporter, SMIT2 (also transports D-chiro-inositol, D-glucose and D-xylose) (Coady et al., 2002; Aouameur et al., 2007).  A 5-state model includes cooperative binding of Na+, strong apparent asymmetry of the energy barriers, a rate limiting step which is likely associated with the translocation of the empty transporter, and a turnover rate of 21 s-1 (Sasseville et al. 2014).

Accession Number:Q8WWX8
Protein Name:Sodium/myo-inositol cotransporter 2
Length:675
Molecular Weight:74036.00
Species: [9606]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate myo-inositol, Na+

Cross database links:

COG4146
Genevestigator: Q8WWX8 Q8WWX8
HEGENOM: HBG585824 HOG000025422
RefSeq: NP_443176.2   
Entrez Gene ID: 115584   
Pfam: PF00474   
OMIM: 610238  gene
KEGG: hsa:115584    hsa:115584   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015293 F:symporter activity
GO:0006915 P:apoptosis
GO:0008643 P:carbohydrate transport
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport
GO:0005886 C:plasma membrane
GO:0006915 P:apoptotic process

References (10)

[1] “New human sodium/glucose cotransporter gene (KST1): identification, characterization, and mutation analysis in ICCA (infantile convulsions and choreoathetosis) and BFIC (benign familial infantile convulsions) families.”  Roll P.et.al.   12039040
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Spina bifida and genetic factors related to myo-inositol, glucose, and zinc.”  Groenen P.M.W.et.al.   15172003
[5] “The sodium-dependent glucose cotransporter SLC5A11 as an autoimmune modifier gene in SLE.”  Tsai L.-J.et.al.   18069935
[6] “New human sodium/glucose cotransporter gene (KST1): identification, characterization, and mutation analysis in ICCA (infantile convulsions and choreoathetosis) and BFIC (benign familial infantile convulsions) families.”  Roll P.et.al.   12039040
[7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “Spina bifida and genetic factors related to myo-inositol, glucose, and zinc.”  Groenen P.M.W.et.al.   15172003
[10] “The sodium-dependent glucose cotransporter SLC5A11 as an autoimmune modifier gene in SLE.”  Tsai L.-J.et.al.   18069935

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MESGTSSPQP PQLDPLDAFP QKGLEPGDIA VLVLYFLFVL AVGLWSTVKT KRDTVKGYFL 
61:	AGGDMVWWPV GASLFASNVG SGHFIGLAGS GAATGISVSA YELNGLFSVL MLAWIFLPIY 
121:	IAGQVTTMPE YLRKRFGGIR IPIILAVLYL FIYIFTKISV DMYAGAIFIQ QSLHLDLYLA 
181:	IVGLLAITAV YTVAGGLAAV IYTDALQTLI MLIGALTLMG YSFAAVGGME GLKEKYFLAL 
241:	ASNRSENSSC GLPREDAFHI FRDPLTSDLP WPGVLFGMSI PSLWYWCTDQ VIVQRTLAAK 
301:	NLSHAKGGAL MAAYLKVLPL FIMVFPGMVS RILFPDQVAC ADPEICQKIC SNPSGCSDIA 
361:	YPKLVLELLP TGLRGLMMAV MVAALMSSLT SIFNSASTIF TMDLWNHLRP RASEKELMIV 
421:	GRVFVLLLVL VSILWIPVVQ ASQGGQLFIY IQSISSYLQP PVAVVFIMGC FWKRTNEKGA 
481:	FWGLISGLLL GLVRLVLDFI YVQPRCDQPD ERPVLVKSIH YLYFSMILST VTLITVSTVS 
541:	WFTEPPSKEM VSHLTWFTRH DPVVQKEQAP PAAPLSLTLS QNGMPEASSS SSVQFEMVQE 
601:	NTSKTHSCDM TPKQSKVVKA ILWLCGIQEK GKEELPARAE AIIVSLEENP LVKTLLDVNL 
661:	IFCVSCAIFI WGYFA