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2.A.21.4.1
The monocarboxylate uptake (H+ symport?) permease, MctP (transports lactate (Km = 4.4 μM), pyruvate (Km = 3.8), propionate, butyrate (butanoic acid), α-hydroxybutyrate, L- and D-alanine (Km = 0.5 mM), and possibly cysteine and histidine) (Hosie et al., 2002).

Accession Number:Q8VM88
Protein Name:MctP
Length:491
Molecular Weight:52258.00
Species:Rhizobium leguminosarum (biovar viciae) [387]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Lactate, pyruvate, Propionate, Butyrate, Alpha-hydroxybutyrate, Alanine, Cysteine, Histidine, H+

Cross database links:

Pfam: PF00474   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005215 F:transporter activity
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “A monocarboxylate permease of Rhizobium leguminosarum is the first member of a new subfamily of transporters.”  Hosie A.H.et.al.   12218032

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTTDINGTAL AVFIFFFVLV TVMGFVASRW RKPETLAHID EWGLGGRNFG TWITWFLVGG 
61:	DFYTAYTVIA VPALVYTVGA YGFFALPYTI VVYPFVFMVM PVLWKRAKDF GYVTAGDVVH 
121:	GQYGSRGLEL AVAATGVIAT MPYIALQLVG MTAVLKALGL HGELPLAIAF IVLALYTYSA 
181:	GLRAPALIAF VKDIMIYIVV IAAVALIPSK LGGYANVFAS ADAAFQAKGS GNLLLGGNQY 
241:	VAYATLALGS ALAAFMYPHT LTGIFASNSG KTIRKNAIML PAYTLLLGLL ALLGYMGHAA 
301:	NLKLDSANDV VPTLFKTLFS GWFFRFAFAA IAIGALVPAA VMSIGAANLF TRNFWKAYVD 
361:	PDVSDAGEAK VAKITSLVVK VGALLVIIFL PTQFALDLQL LGGIWILQTL PALVFGLYTN 
421:	WFRAPGLLAG WFVGFGGGTF LVWDAGWKPL HLISLGGEPF TVYTGLLALA ANIAVAVVVN 
481:	ALLPAKAPVR A