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2.A.21.5.2
Na+-dependent multivitamin (pantothenate, biotin, lipoate) transporter (de Carvalho and Quick 2011). Broad specificity. May be useful for drug delivery using biotin-conjugated drugs such as Biotin-Acyclovir (B-ACV) (Vadlapudi et al. 2012).  Present in the inclusion membrane that encases Chlamydia trachomatis where it transports vitamins such as biotin (Fisher et al. 2012).  May also take up iodide (de Carvalho and Quick 2011).

Accession Number:O70247
Protein Name:SL56 aka SMVT aka SLC5A6
Length:634
Molecular Weight:68642.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+, Pantothenate, Biotin, Lipoate

Cross database links:

Genevestigator: O70247
eggNOG: roNOG15343
RefSeq: NP_570102.1   
Entrez Gene ID: 170551   
Pfam: PF00474   
KEGG: rno:170551   

Gene Ontology

GO:0031526 C:brush border membrane
GO:0016021 C:integral to membrane
GO:0012506 C:vesicle membrane
GO:0008523 F:sodium-dependent multivitamin transmembrane...
GO:0015878 P:biotin transport
GO:0015887 P:pantothenate transmembrane transport
GO:0006814 P:sodium ion transport

References (1)

[1] “Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate.”  Prasad P.D.et.al.   9516450

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTVASTAAPS YTTSDTNRVI STFSVVDYVV FGLLLVLSLV IGLYHACRGW GRHTVGELLM 
61:	ADRKMGCLPV ALSLLATFQS AVAILGGPAE IYRFGTQYWF LGCSYFLGLL IPAHIFIPVF 
121:	YRLHLTSAYE YLELRFNKAV RICGTVTFIF QMVVYMGVAL YAPSLALNAV TGFDLWLSVL 
181:	ALGIVCNIYT ALGGLKAVIW TDVFQTLIMF LGQLVVIIVG AAKVGGLGHV WAVASQHGLI 
241:	SGIELDPDPF VRHTFWTLAF GGVFMMLSLY GVNQAQVQRY LSSHSEKAAV LSCYAVFPCQ 
301:	QVALCMSCLI GLVMFAYYKK YSMSPQQEQA APDQLVLYFV MDLLKDMPGL PGLFVACLFS 
361:	GSLSTISSAF NSLATVTMED LIQPWFPQLT ETRAIMLSRS LAFAYGLVCL GMAYVSSHLG 
421:	SVLQAALSIF GMVGGPLLGL FCLGMFFPCA NPLGAIVGLL TGLTMAFWIG IGSIVSRMSS 
481:	AAASPPLNGS SSFLPSNLTV ATVTTLMPST LSKPTGLQQF YSLSYLWYSA HNSTTVIAVG 
541:	LIVSLLTGGM RGRSLNPGTI YPVLPKLLAL LPLSCQKRLC WRSHNQDIPV VTNLFPEKMG 
601:	NGALQDSRDK ERMAEDGLVH QPCSPTYIVQ ETSL