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2.A.21.5.4
The low affinity (Km (lactate) = 2mM) electroneutral Na+:monocarboxylate (lactate, pyruvate, butyrate, nicotinate) transporter, SMCTn (Plata et al., 2007)

Accession Number:Q7T384
Protein Name:Solute carrier family 5 (Sodium/glucose cotransporter), member 12 aka smctn
Length:623
Molecular Weight:67320.00
Species:Danio rerio (Zebrafish) (Brachydanio rerio) [7955]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Lactate, pyruvate, Butyrate, Nicotinate, H+

Cross database links:

eggNOG: fiNOG04311
RefSeq: NP_956662.1   
Entrez Gene ID: 393339   
Pfam: PF00474   
KEGG: dre:393339   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015355 F:secondary active monocarboxylate transmembr...
GO:0015293 F:symporter activity
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Zebrafish Slc5a12 encodes an electroneutral sodium monocarboxylate transporter (SMCTn). A comparison with the electrogenic SMCT (SMCTe/Slc5a8).”  Plata C.et.al.   17255103

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	METVGRFQAG DYVVFACLFV VSSGIGVFFA IKERNKAPSK EFLVGGRQMS CGPVALSLTA 
61:	SFMSAVTVIG APADVYRFGA SYVIFGVAYT FVVFFTAELF LPVFYRSGIT STYEYLELRF 
121:	CKLVRVAATL IYIIQTILYT GVVVYAPALA LNQVTGFDLW GSIFATGIVC TFYCTLGGLK 
181:	AVVWTDAFQM VVMVVGFLTV LIQGSSRAGG IENVWSTSRT GGRLQVFDFD VSPLRRHTFW 
241:	TLSVGGTFTW LGIYGVNQST IQRCISCKTE GHARWALYLN LLGLWIILFC AVVSGLIMYS 
301:	YYSHCDPWSS GLISAPDQLM PYFVMEILGA FPGLPGLFVA CAFSGTLSTV AASINALATV 
361:	MYEDFVSQCF PDLSNRAASW ISKALCVAFG VACTTMAVAA SYMGGIVQAA LSIHGMCGGP 
421:	VLGLFSLGIL FPFTNLKGAV GGLIVGISLS FWVGVGAFIY PAPSNNTHAL ELNTAGCNIT 
481:	AAAFEPTSAT VTQLTSDRNW LADSWYSMSY LYYSAVGFIG TVAAGLLITL LTGPMDPKLL 
541:	KPGMTRSVKE VMCFCTEKFT EADLGEGKED VGDFGKAWEK HPDQGCTLRM DEKFRCSCDN 
601:	QQENGNTNAG FDHNETSIVQ KKL