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2.A.21.5.5
The high affinity (Km (lactate) = 0.2mM) electrogenic Na+ monocarboxylate (lactate, pyruvate, butyrate, nicotinate) transporter, SMCTe (Plata et al., 2007).

Accession Number:Q3ZMH1
Protein Name:Electrogenic sodium monocarboxylate cotransporter aka smcte
Length:610
Molecular Weight:66359.00
Species:Danio rerio (Zebrafish) (Brachydanio rerio) [7955]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Lactate, pyruvate, Butyrate, Nicotinate, Na+

Cross database links:

eggNOG: fiNOG04311
HEGENOM: HBG446891
RefSeq: NP_001030141.1   
Entrez Gene ID: 556156   
Pfam: PF00474   
KEGG: dre:556156   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015355 F:secondary active monocarboxylate transmembr...
GO:0015293 F:symporter activity
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Zebrafish Slc5a12 encodes an electroneutral sodium monocarboxylate transporter (SMCTn). A comparison with the electrogenic SMCT (SMCTe/Slc5a8).”  Plata C.et.al.   17255103

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPGSGGPVAT FSVWDYVVFA GLILVAAGIG LFQSFRGRKE ASSDEFLLGG RQMTAVPVAL 
61:	SLTASFMSGI TVIGTPAEAY LYGTPFWLFF ISYAIMSTIS AEIFVPLFYR LNITSTYEYL 
121:	EMRYNKLIRV IGTSMYIIQT ALYTGMVIFA PALALNQITG LDLWGVLVAT GAVCIIYCTL 
181:	GGLKAVIWTD VFQMIIMLGG FVAVIARGAV LQGGLGRVWN DSFYGGRLET FSFDPDPLRR 
241:	HSFWTIVVGG SLMWASMYSI NQSQVQRYIS CRTMTHAKLS LYVNMVGLWV TVSLAMMSGL 
301:	TMYSIYKDCD PFTNKDVGAT DQLLPYLVMD ILADFPGLPG LFVAAAYSGT LSTVSSSINA 
361:	LVAVTVEDFM KPAWPSLTER QLSWINMGMS VFYGAVCIGM AGVASMMGNI LQAALSIFGM 
421:	ISGPLLGLYM LGMFFRCANS TGGLAGLASG LAITLWVGIG AQLYPPLPEK TLRLPLSVEG 
481:	CVALNTSETT TMTPFSTVLQ TTTPQPRPAL ADNWYSLSYL YFSPVGIVVT MIIALIVSAI 
541:	SGGCKQKKVR PELFISKSDL ICFRCKKSDS EVSDLIETKP KDNQGLDSPV FYDNEIVLKE 
601:	KDQQEKITKL