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2.A.21.5.6
Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12)

Accession Number:Q1EHB4
Protein Name:Sodium-coupled monocarboxylate transporter 2
Length:618
Molecular Weight:67647.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Apical cell membrane1 / Multi-pass membrane protein2
Substrate Monocarboxylates, Na+

Cross database links:

Genevestigator: Q1EHB4
eggNOG: COG0591
HEGENOM: HOG000261662
Entrez Gene ID: 159963   
Pfam: PF00474   
KEGG: hsa:159963   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0016021 C:integral to membrane
GO:0015293 F:symporter activity
GO:0006814 P:sodium ion transport

References (3)

[1] “Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney.”  Gopal E.et.al.   17692818
[2] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MEVKNFAVWD YVVFAALFFI SSGIGVFFAI KERKKATSRE FLVGGRQMSF GPVGLSLTAS 
61:	FMSAVTVLGT PSEVYRFGAS FLVFFIAYLF VILLTSELFL PVFYRSGITS TYEYLQLRFN 
121:	KPVRYAATVI YIVQTILYTG VVVYAPALAL NQVTGFDLWG SVFATGIVCT FYCTLGGLKA 
181:	VVWTDAFQMV VMIVGFLTVL IQGSTHAGGF HNVLEQSTNG SRLHIFDFDV DPLRRHTFWT 
241:	ITVGGTFTWL GIYGVNQSTI QRCISCKTEK HAKLALYFNL LGLWIILVCA VFSGLIMYSH 
301:	FKDCDPWTSG IISAPDQLMP YFVMEIFATM PGLPGLFVAC AFSGTLSTVA SSINALATVT 
361:	FEDFVKSCFP HLSDKLSTWI SKGLCLLFGV MCTSMAVAAS VMGGVVQASL SIHGMCGGPM 
421:	LGLFSLGIVF PFVNWKGALG GLLTGITLSF WVAIGAFIYP APASKTWPLP LSTDQCIKSN 
481:	VTATGPPVLS SRPGIADTWY SISYLYYSAV GCLGCIVAGV IISLITGRQR GEDIQPLLIR 
541:	PVCNLFCFWS KKYKTLCWCG VQHDSGTEQE NLENGSARKQ GAESVLQNGL RRESLVHVPG 
601:	YDPKDKSYNN MAFETTHF