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2.A.21.5.7
Sodium-dependent multivitamin transporter (Na+-dependent multivitamin transporter) (Solute carrier family 5 member 6)

Accession Number:Q9Y289
Protein Name:Sodium-dependent multivitamin transporter
Length:635
Molecular Weight:68642.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Vitamins, Na+

Cross database links:

Genevestigator: Q9Y289
eggNOG: COG0591
HEGENOM: HOG000261662
Entrez Gene ID: 8884   
Pfam: PF00474   
KEGG: hsa:8884   

Gene Ontology

GO:0031526 C:brush border membrane
GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0012506 C:vesicle membrane
GO:0008523 F:sodium-dependent multivitamin transmembrane transporter activity
GO:0006768 P:biotin metabolic process
GO:0015878 P:biotin transport
GO:0015939 P:pantothenate metabolic process
GO:0015887 P:pantothenate transmembrane transport

References (5)

[1] “Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization.”  Wang H.et.al.   10329687
[2] “Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter.”  Prasad P.D.et.al.   10334869
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSVGVSTSAP LSPTSGTSVG MSTFSIMDYV VFVLLLVLSL AIGLYHACRG WGRHTVGELL 
61:	MADRKMGCLP VALSLLATFQ SAVAILGVPS EIYRFGTQYW FLGCCYFLGL LIPAHIFIPV 
121:	FYRLHLTSAY EYLELRFNKT VRVCGTVTFI FQMVIYMGVV LYAPSLALNA VTGFDLWLSV 
181:	LALGIVCTVY TALGGLKAVI WTDVFQTLVM FLGQLAVIIV GSAKVGGLGR VWAVASQHGR 
241:	ISGFELDPDP FVRHTFWTLA FGGVFMMLSL YGVNQAQVQR YLSSRTEKAA VLSCYAVFPF 
301:	QQVSLCVGCL IGLVMFAYYQ EYPMSIQQAQ AAPDQFVLYF VMDLLKGLPG LPGLFIACLF 
361:	SGSLSTISSA FNSLATVTME DLIRPWFPEF SEARAIMLSR GLAFGYGLLC LGMAYISSQM 
421:	GPVLQAAISI FGMVGGPLLG LFCLGMFFPC ANPPGAVVGL LAGLVMAFWI GIGSIVTSMG 
481:	SSMPPSPSNG SSFSLPTNLT VATVTTLMPL TTFSKPTGLQ RFYSLSYLWY SAHNSTTVIV 
541:	VGLIVSLLTG RMRGRSLNPA TIYPVLPKLL SLLPLSCQKR LHCRSYGQDH LDTGLFPEKP 
601:	RNGVLGDSRD KEAMALDGTA YQGSSSTCIL QETSL