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2.A.21.6.1
Urea active transporter (also transports polyamines; Uemura et al., 2007; Kashiwagi and Igarashi, 2011).

Accession Number:P33413
Protein Name:DUR3 aka YHL016C
Length:735
Molecular Weight:80617.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:15
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Urea, Polyamines

Cross database links:

Genevestigator: P33413
eggNOG: fuNOG05012
HEGENOM: HBG397209
RefSeq: NP_011847.1   
Entrez Gene ID: 856370   
Pfam: PF00474   
KEGG: sce:YHL016C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005515 F:protein binding
GO:0015489 F:putrescine transmembrane transporter activity
GO:0015606 F:spermidine transmembrane transporter activity
GO:0015204 F:urea transmembrane transporter activity
GO:0015847 P:putrescine transport
GO:0015848 P:spermidine transport
GO:0055085 P:transmembrane transport
GO:0043419 P:urea catabolic process
GO:0015840 P:urea transport

References (4)

[1] “Regulation of the urea active transporter gene (DUR3) in Saccharomyces cerevisiae.”  Elberry H.M.et.al.   8335627
[2] “Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII.”  Johnston M.et.al.   8091229
[3] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGEFKPPLPQ GAGYAIVLGL GAVFAGMMVL TTYLLKRYQK EIITAEEFTT AGRSVKTGLV 
61:	AAAVVSSWIW CSTLLTSSTK EYADGIFGGY AYAAGACFQI IAFAILAIKT KQMAPNAHTY 
121:	LELVRTRYGK IGHGCYLFYA IATNILVTSM LLTSGSAVFS DLTGMNTIAS CFLLPVGVVV 
181:	YTLFGGIKAT FLTDYMHTCV IIIIVLVFAF KVYATSDVLG SPGKVYDLVR EAAKRHPVDG 
241:	NYQGEYMTMT SKSAGILLII NLIGNFGTVF LDNGYWNKAI SASPAASLKA YAIGGLAWFA 
301:	VPSLISLTMG LACLAVETSP NFPTYPDPLT SFQANSGLVL PAAAIAIMGK GGAVASLLMI 
361:	FMAVTSAMSA ELIAVSSVFT YDIYREYIDP RASGKKLIYT SHVACIFFGL AMSGFSVGLY 
421:	YGGISMGYIY EMMGIIISSA VLPVVLTLCS KDMNLVAAVV SPILGTGLAI MSWLVCTKSL 
481:	YKELTVDTTF MDYPMLTGNL VALLSPAIFI PILTYVFKPQ NFDWEKMKDI TRVDETAELV 
541:	QADPDIQLYD AEANDKEQEE ETNSLVSDSE KNDVRVNNEK LIEPNLGVVI SNAIFQEDDT 
601:	QLQNELDEEQ RELARGLKIA YFLCVFFALA FLVVWPMPMY GSKYIFSKKF FTGWVVVMII 
661:	WLFFSAFAVC IYPLWEGRHG IYTTLRGLYW DLSGQTYKLR EWQNSNPQDL HVVTSQISAR 
721:	AHRQSSHFGQ VDEII