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2.A.21.6.6
Urea transporter, UreA of 693 aas.  A three-dimensional model of UreA which, combined with mutagenesis studies, led to the identification of residues important for binding, recognition and translocation of urea, and in the sorting of UreA to the membrane. Residues W82, Y106, A110, T133, N275, D286, Y388, Y437 and S446, located in transmembrane helixes 2, 3, 7 and 11, were found to be involved in the binding, recognition and/or translocation of urea and the sorting of UreA to the membrane. Y106, A110, T133 and Y437 seem to play a role in substrate selectivity, while S446 is necessary for proper sorting of UreA to the membrane (Sanguinetti et al. 2014).

Accession Number:E5CZT5
Protein Name:Urea active transporter
Length:693
Molecular Weight:74235.00
Species:Emericella nidulans [162425]
Number of TMSs:17
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Urea

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FASTA formatted sequence
1:	MVAVIAAPDE AGVETVTFTA PLTQGFGYGI IIGLGFAFAL VMIFITWSLK RYQHEIITSE 
61:	MFSTAGRSVK SGLVASAVVS SWTWAATLLQ SSAVAYQYGT SGPFFYASGA TVQIILFATL 
121:	AIELKRRAPN AHTFLEAIRA RYGTVVHLVF IVFCLMTNIL VTAMLLTGGA AVLNSMTGVP 
181:	VVAACFLLPI GVVLYTLFGG IKATFITDYM HTVVIVVIIF IFAFSAYASN DRLGSPGKVY 
241:	DLLVQAALRN PVSGNAEGSY LTMRSKDGGI FWVINLVGNF GTVFLDNGYY NKAIAAHPVH 
301:	AFPGYVIGGL CWFAIPWLCA TTMGLSALAL EGTRRIASVD VTAGLVLPFA SVELLGYSGA 
361:	VCTTLMIFMA VTSAFSAQLI AVSSILTYDI YQAYINPAAK GKRLVWVSHL SCVVFAIAMA 
421:	AFATGLHYAG IGMGYLYLLM GVIISSAVFP GAMTLVWKGQ NWIAAAASPV LGLAMSLVAW 
481:	LVTTKTEYGV FTVETTGANY PMLAGNVAAL LSPVVFSPVL TYLFGPQNYD YESMRAIRKV 
541:	DDSDVAAAAH VDLELIPGAS NTNSSPSQQQ QEEEEIRKLN KAAFISRCLT VGMVICFLIL 
601:	WPIPMYGSGY VFSKKFFTGW VVVGIIWLFG TAFGVILFPL WEGRSSIKRV GKLMLLDAMG 
661:	RQWKSSALVG QGDEESEESG SGAVTPSEKI VAK