TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.21.8.1
High affinity neuronal choline:Na+ symporter, CHT1 (chloride-dependent).  Present in presynaptic terminals of cholinergic neurons.  Has 13 TMSs (Haga 2014).

Accession Number:Q9JMD7
Protein Name:CHT1
Length:580
Molecular Weight:63407.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Choline, Na+

Cross database links:

Genevestigator: Q9JMD7
eggNOG: roNOG09602
RefSeq: NP_445973.1   
Entrez Gene ID: 85426   
Pfam: PF00474   
KEGG: rno:85426   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0008292 P:acetylcholine biosynthetic process
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Identification and characterization of the high-affinity choline transporter.”  Okuda T.et.al.   10649566

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MPFHVEGLVA IILFYLLIFL VGIWAAWKTK NSGNAEERSE AIIVGGRDIG LLVGGFTMTA 
61:	TWVGGGYING TAEAVYGPGC GLAWAQAPIG YSLSLILGGL FFAKPMRSKG YVTMLDPFQQ 
121:	IYGKRMGGLL FIPALMGEMF WAAAIFSALG ATISVIIDVD VNISVIVSAL IAILYTLVGG 
181:	LYSVAYTDVV QLFCIFIGLW ISVPFALSHP AVTDIGFTAV HAKYQSPWLG TIESVEVYTW 
241:	LDNFLLLMLG GIPWQAYFQR VLSSSSATYA QVLSFLAAFG CLVMALPAIC IGAIGASTDW 
301:	NQTAYGFPDP KTKEEADMIL PIVLQYLCPV YISFFGLGAV SAAVMSSADS SILSASSMFA 
361:	RNIYQLSFRQ NASDKEIVWV MRITVFVFGA SATAMALLTK TVYGLWYLSS DLVYIIIFPQ 
421:	LLCVLFIKGT NTYGAVAGYI FGLFLRITGG EPYLYLQPLI FYPGYYPDKN GIYNQRFPFK 
481:	TLSMVTSFFT NICVSYLAKY LFESGTLPPK LDIFDAVVSR HSEENMDKTI LVRNENIKLN 
541:	ELAPVKPRQS LTLSSTFTNK EALLDVDSSP EGSGTEDNLQ