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TCID	Name	Organismal Type	Example
2.A.21.1.1	Pantothenate:Na⁺ symporter	Bacteria	PanF of E. coli
2.A.21.2.1	Proline:Na⁺ symporter	Bacteria	PutP of E. coli
2.A.21.3.1	Glucose or galactose:Na⁺ symporter (galactose > glucose > fucose). Cotransports water against an osmotic gradient (Naftalin, 2008). TMS IV of the high-affinity sodium-glucose cotransporter participates in sugar binding (Liu et al., 2008).	Animals	SGLT of Homo sapiens
2.A.21.3.2	Glucose or galactose:Na⁺ symporter. The 3.0Å structure is known (Faham et al., 2008).	Bacteria	SglS of Vibrio parahaemolyticus
2.A.21.3.3	Nucleoside or glucose(?):Na⁺ symporter	Animals	SNST of Oryctolagus cuniculus
2.A.21.3.4	Glucose:Na⁺ symporter 3 (low affinity)	Animals	SAAT1 of Sus scrofa
2.A.21.3.5	Myoinositol:Na⁺ symporter, SMIT1 (Aouameur et al., 2007).	Animals	SMIT of Canis familiaris
2.A.21.3.6	Myoinositol:Na⁺ symporter, SMIT2 (also transports D-chiro-inositol, D-glucose and D-xylose) (Coady et al., 2002; Aouameur et al., 2007)	Animals	SMIT2 of Homo sapiens
2.A.21.3.7	Putative sialic acid uptake permease, NanP (D.A. Rodionov, pers. commun.)	Bacteria	NanP of Vibrio fischeri (Q5E733)
2.A.21.3.8	The putative mannose porter, ManP^ll	Proteobacteria	ManP^ll of Shewanella amazonensis (A1S2A8)
2.A.21.3.9	The putative galactose porter, GalP^ll	Proteobacteria	GalP^llof Shewanella pealeana (A8H019)
2.A.21.3.10	The putative sialic acid porter, NanP	Proteobacteria, Firmicutes, Mollicutes	NanP of Salmonella typhimurium (Q8ZQ35)
2.A.21.4.1	The monocarboxylate uptake (H⁺ symport?) permease, MctP (transports lactate, pyruvate, propionate, butyrate, α-hydroxybutylate, L- and D-alanine, and possibly cysteine and histidine)	Bacteria	MctP of Rhizobium leguminosarum
2.A.21.5.1	Sodium iodide symporter (also transports other monovalent anions including: ClO₃^-, SCN^-, SeCN^-, NO₃^-, Br^-, BF₄^-, IO₄^- and BrO₃^-). Also mediates electroneutral active transport of the environmental pollutant perchlorate (Dohan et al., 2007)	Animals	Na⁺I^- symporter of Homo sapiens
2.A.21.5.2	Na⁺-dependent multivitamin (pantothenate, biotin, lipoate) transporter	Animals	SMVT of Rattus norvegicus
2.A.21.5.3	Na⁺-dependent short chain fatty acid transporter SLC5A8 (tumor suppressor gene product, down-regulated in colon cancer) (substrates: lactate, pyruvate, acetate, propionate, butyrate (Km ≈1 mM)) [propionate:Na⁺ = 1:3] (Miyauchi et al., 2004). Pyroglutamate (5-oxoproline) is also transported in a Na⁺- coupled mechanism (Miyauchi et al., 2010). SMCT1 and SMCT2 may transport monocarboxylate drugs (e.g. nicotinate and its derivatives) across the intestinal brush boarder membrane (Gopal et al., 2007; Frank et al. 2008). Wilson et al., 2009 have proposed mechanistic details.	Animals	Short chain organic acid:Na⁺ symporter of Homo sapiens, SLC5A8 (Q7Z2H9)
2.A.21.5.4	The low affinity (Km (lactate) = 2mM) electroneutral Na⁺:monocarboxylate (lactate, pyruvate, butyrate, nicotinate) transporter, SMCTn (Plata et al., 2007)	Animals	SMCTn of Danio rerio (Q7T384)
2.A.21.5.5	The high affinity (Km (lactate) = 0.2mM) electrogenic Na⁺ monocarboxylate (lactate, pyruvate, butyrate, nicotinate) transporter, SMCTe (Plata et al., 2007).	Animals	SMCTe of Danio rerio (Q3ZMH1)
2.A.21.6.1	Urea active transporter (also transports polyamines; Uemura et al., 2007)	Animals	DUR3 of Saccharomyces cerevisiae
2.A.21.6.2	The major transporter for high-affinity urea transport across the plasma membrane of nitrogen-deficient Arabidopsis roots, Dur3 (Kojima et al., 2006; Mérigout et al., 2008)	Plants	Dur3 of Arabidopsis thaliana (Q9FHJ8)
2.A.21.7.1	Phenylacetate permease, Ppa	Bacteria	Phenylacetate permease Ppa of Pseudomonas putida
2.A.21.7.2	Acetate/glyoxalate permease, ActP (Gimenez et al., 2003)	Bacteria	ActP (YjcG) of E. coli (NP_418491)
2.A.21.7.3	Pyruvate/acetate/propionate: H⁺ symporter, MctC (DhlC; cg0953).	Bacteria	MctC of Corynebacterium glutamicum (Q8NS49)
2.A.21.8.1	High affinity neuronal choline: Na⁺ symporter, CHT1 (chloride-dependent)	Animals	CHT1 of Rattus norvegicus
2.A.21.9.1	The nitrogen sensor-receptor domain of the CbrA sensor kinase	Bacteria	CbrA sensor domain of Pseudomonas aeruginosa
2.A.21.9.2	The proline sensor-receptor domain of the PrlS sensor kinase	Bacteria	PrlS of Aeromonas hydrophila