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2.A.21.9.1
The nitrogen sensor-receptor domain of the CbrA sensor kinase

Accession Number:Q9HV74
Protein Name:CbrA aka P4725
Length:983
Molecular Weight:108381.00
Species:Pseudomonas aeruginosa [287]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

HEGENOM: HBG336928
RefSeq: NP_253413.1   
Entrez Gene ID: 881602   
Pfam: PF02518    PF00512    PF00989   
BioCyc: PAER208964:PA4725-MONOMER   
KEGG: pae:PA4725   

Gene Ontology

GO:0016020 C:membrane
GO:0005524 F:ATP binding
GO:0005215 F:transporter activity
GO:0000155 F:two-component sensor activity
GO:0018106 P:peptidyl-histidine phosphorylation
GO:0006355 P:regulation of transcription, DNA-dependent
GO:0007165 P:signal transduction
GO:0055085 P:transmembrane transport

References (2)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043
[2] “The CbrA-CbrB two-component regulatory system controls the utilization of multiple carbon and nitrogen sources in Pseudomonas aeruginosa.”  Hishijyo T.et.al.   11401699

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLTSFSLTQL ILISVTYLST LFGIAWITER GYVPRRLVRH PLVYTLSLGV YASAWAFYGT 
61:	VGLAYQYGYG FLAIYLGISG AFLLAPVLLY PILRVTRAYQ LSSLADLFAF RFRSTWAGAL 
121:	TTLFMLIGVL PMLALQIQAV TDSISILTRD PAQERVAFVF CTLITLFAIL FGARHIATRE 
181:	RHEGLVFAIA FESLVKLVML GSIGLYALYG VFGGPEGLEV WLLQNQTALT TLHTPLAEGP 
241:	WRTLLLVFFA AAIVMPHMFH MIFTENLNPR ALISASWGLP LFLLLMSLAV PPILWAGLRL 
301:	GASTTPEYYT IGLGLAVDSP ALALAAFIGG ISAASGLTIV MTLALSGMVL NHLVLPLYQP 
361:	PAQGNIYRWL KWTRRLLIVA IIMASYAFYL LLGAEQDLSN LGIVSFVATL QFLPGALSVL 
421:	YWPTANRRGF ISGLIAGMLV WAITMLLPLM GNVQGLYLPL FDVIYVLDDS NWHLAALSSL 
481:	AANVLVFTLV SLFTEASDEE KGAAEACAVD NVRRPQRREL FAGSPQEFAS QLAKPLGAKT 
541:	AQKEVEQALR DLHLPFDERR PYALRRLRDR IEANLSGLMG PSVAQDIVET FLPYKTSEES 
601:	YVTEDIHFIE SRLEDYHSRL TGLAAELDTL RRYHRQTLQD LPMGVCSLAK DQEVLMWNRA 
661:	IEELTGVGAQ KVVGSRLSAL PEPWKGLLER FIDAPDEHLH KQRLVYDGHT RWLNLHKAAI 
721:	EEPLAPGNSG LVLLVEDLTE TQLLEDKLVH SERLASIGRL AAGVAHEIGN PITGIACLAQ 
781:	NLREEREGDG ELTEISEQIL DQTKRVSRIV QSLMSFAHSG SHLQALEPVC LSEVAQEAIG 
841:	LLSLNRRSVE VEFFNLCDPA HWVEGDSQRL AQVLINLLSN ARDASPPGGA IRVRSEASEH 
901:	TVDLVVEDEG SGIPKAIMDQ LFEPFFTTKD PGKGTGLGLA LVYSIVEEHY GQITIESPTD 
961:	HQREGGTRFR VTLPRHPGPT AEL