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|---|---|
| Accession Number: | P31645 |
| Protein Name: | NTSE aka SLC6A4 aka HTT aka SERT |
| Length: | 630 |
| Molecular Weight: | 70325.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 11 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Cross database links:
| Genevestigator: | P31645 P31645 |
|---|---|
| eggNOG: | prNOG09075 COG0733 |
| HEGENOM: | HBG702834 HOG000116406 |
| RefSeq: | NP_001036.1 |
| Entrez Gene ID: | 6532 |
| Pfam: | PF03491 PF00209 |
| Drugbank: | Drugbank Link |
| OMIM: |
103780 phenotype 164230 phenotype 182138 gene |
| KEGG: | hsa:6532 hsa:6532 |
Gene Ontology
GO:0005829
C:cytosol
GO:0005887
C:integral to plasma membrane
GO:0008022
F:protein C-terminus binding
GO:0015222
F:serotonin transmembrane transporter activity
GO:0005335
F:serotonin:sodium symporter activity
GO:0009636
P:response to toxin
GO:0051610
P:serotonin uptake
GO:0021794
P:thalamus development
GO:0012505
C:endomembrane system
GO:0010008
C:endosome membrane
GO:0045121
C:membrane raft
GO:0019717
C:synaptosome
GO:0019811
F:cocaine binding
GO:0048854
P:brain morphogenesis
GO:0071321
P:cellular response to cGMP
GO:0071300
P:cellular response to retinoic acid
GO:0007623
P:circadian rhythm
GO:0007613
P:memory
GO:0021941
P:negative regulation of cerebellar granule cell precursor proliferation
GO:0045665
P:negative regulation of neuron differentiation
GO:0046621
P:negative regulation of organ growth
GO:0032227
P:negative regulation of synaptic transmission, dopaminergic
GO:0045787
P:positive regulation of cell cycle
GO:0010628
P:positive regulation of gene expression
GO:0051260
P:protein homooligomerization
GO:0051259
P:protein oligomerization
GO:0042493
P:response to drug
GO:0032355
P:response to estradiol stimulus
GO:0001666
P:response to hypoxia
GO:0035176
P:social behavior
GO:0042713
P:sperm ejaculation
GO:0042310
P:vasoconstriction
| |
References (26)[1] “Isolation of a cDNA encoding the human brain serotonin transporter.” Lesch K.P.et.al. 8452685 [2] “Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization.” Ramamoorthy S.et.al. 7681602 [3] “Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter.” Lesch K.P.et.al. 7684072 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter.” Carneiro A.M.D.et.al. 16803896 [6] “Characterization of single-nucleotide polymorphisms in coding regions of human genes.” Cargill M.et.al. 10391209 [7] “Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype.” Ozaki N.et.al. 14593431 [8] “A human serotonin transporter mutation causes constitutive activation of transport activity.” Kilic F.et.al. 12869649 [9] “Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.” Caspi A.et.al. 12869766 [10] “Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence.” Feinn R.et.al. 15635638 [11] “Isolation of a cDNA encoding the human brain serotonin transporter.” Lesch K.P.et.al. 8452685 [12] “Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization.” Ramamoorthy S.et.al. 7681602 [13] “Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter.” Lesch K.P.et.al. 7684072 [14] “Molecular characterization and intracellular regulation of the human serotonin transporter in Caco-2 cells.” Iceta R.et.al. 16601320 [15] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [16] “Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter.” Carneiro A.M.D.et.al. 16803896 [17] “Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2.” Mueller H.K.et.al. 16870614 [18] “Plasma serotonin levels and the platelet serotonin transporter.” Brenner B.et.al. 17506858 [19] “Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter.” Ahmed B.A.et.al. 18227069 [20] “The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network.” Ahmed B.A.et.al. 19270731 [21] “Tyrosine phosphorylation of the human serotonin transporter: a role in the transporter stability and function.” Annamalai B.et.al. 21992875 [22] “Characterization of single-nucleotide polymorphisms in coding regions of human genes.” Cargill M.et.al. 10391209 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | |||
| FASTA formatted sequence |
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1: METTPLNSQK QLSACEDGED CQENGVLQKV VPTPGDKVES GQISNGYSAV PSPGAGDDTR 61: HSIPATTTTL VAELHQGERE TWGKKVDFLL SVIGYAVDLG NVWRFPYICY QNGGGAFLLP 121: YTIMAIFGGI PLFYMELALG QYHRNGCISI WRKICPIFKG IGYAICIIAF YIASYYNTIM 181: AWALYYLISS FTDQLPWTSC KNSWNTGNCT NYFSEDNITW TLHSTSPAEE FYTRHVLQIH 241: RSKGLQDLGG ISWQLALCIM LIFTVIYFSI WKGVKTSGKV VWVTATFPYI ILSVLLVRGA 301: TLPGAWRGVL FYLKPNWQKL LETGVWIDAA AQIFFSLGPG FGVLLAFASY NKFNNNCYQD 361: ALVTSVVNCM TSFVSGFVIF TVLGYMAEMR NEDVSEVAKD AGPSLLFITY AEAIANMPAS 421: TFFAIIFFLM LITLGLDSTF AGLEGVITAV LDEFPHVWAK RRERFVLAVV ITCFFGSLVT 481: LTFGGAYVVK LLEEYATGPA VLTVALIEAV AVSWFYGITQ FCRDVKEMLG FSPGWFWRIC 541: WVAISPLFLL FIICSFLMSP PQLRLFQYNY PYWSIILGYC IGTSSFICIP TYIAYRLIIT 601: PGTFKERIIK SITPETPTEI PCGDIRLNAV
