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2.A.22.1.5
High affinity octopamine transporter, OAT (also transports tyramine and dopamine in the 0.4-3.0 μM range (Donly et al., 2007)).

Accession Number:Q95VZ4
Protein Name:High-affinity octopamine transporter
Length:744
Molecular Weight:82678.00
Species:Trichoplusia ni PE=2 SV=2 [7111]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Octopamine, Tyramine, dopamine

Cross database links:

Pfam: PF00209   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0006836 P:neurotransmitter transport

References (1)

[1] “A high-affinity octopamine transporter cloned from the central nervous system of cabbage looper Trichoplusia ni.”  Malutan T.et.al.   11804806

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAGMPVLGNS VGAGELRDTS REASNRSSSS GSRRGSSPHH AQDHETCDAT VHKPDLTRTR 
61:	PTSYDREYHD KVPTMATLSG TGVVTHTAPS YEEQRANPAL LSRGASGTPG GRSVRDDGYC 
121:	SASSTPRAFD NKSTKGSVVT LSCYKKEPKI QIEEECFYSE PNKRLRTNSI KTEADDGRET 
181:	WGTGADFLLS IIGFAVDLAN VWRFPYLCYR NGGGAFLIPY TLMLVFGAVP LFYMELILGQ 
241:	YNRQGPITLW KICPLFKGVG FCAVMVAFYV SFYYNVIIGW AFYFLVSSAR SELPWVHCDN 
301:	SWNTDQCWDS GRDNATNRTD VRYQGPLSHF TPASEFFHRA VLEMQNSEGL NDLGFPKWQL 
361:	AICLGLVYVT LYLSLFKGVK SSGKVVWMTA TMPYVVLSIL LARGLLLPGA TRGIAYYLQP 
421:	ELTRLKDTQV WVDAAVQIFY SVGAGFGVHL SYASYNTFHN NCYRDCLVTT LVNCFTSFFS 
481:	GFVIFTYLGF MSHKQGVPIS SVATEGPGLV FQVYPEAVAT LPGASLWAML FFFMLIMLGL 
541:	DSGMGGLECV ITGLLDQARA CGATWLRREH FTLIVVCVSF CVACINVTPG GIYMFHLLDT 
601:	YAAGISLLCS ALFEAVAVSW FYGLKRFSDD VEEMLGFRPG LYWRICWKFV SPTFIIGVVV 
661:	FGLLYQQPLQ YQQYTYPPWA VVLGWGLACS SILMIPVVGI YKLISTPGTF RERVACCISP 
721:	ESEHEAIRGG APVSRFSWRH WLYV