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2.A.22.1.9
The sodium-dependent serotonin transporter of 622 aas and 12 TMSs, SerT.  Terminates the action of serotonin by its high affinity reuptake into presynaptic terminals (Demchyshyn et al. 1994). Substrates have been predicted based on modeling studies (Kaufmann et al. 2009).

Accession Number:P51905
Protein Name:Sodium-dependent serotonin transporter
Length:622
Molecular Weight:69326.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate serotonin, Na+

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDRSGSSDFA GAAATTGRSN PAPWSDDKES PNNEDDSNED DGDHTTPAKV TDPLAPKLAN 
61:	NERILVVSVT ERTRETWGQK AEFLLAVIGF AVDLGNVWRF PYICYQNGGG AFLVPYCLFL 
121:	IFGGLPLFYM ELALGQFHRC GCLSIWKRIC PALKGVGYAI CLIDIYMGMY YNTIIGWAVY 
181:	YLFASFTSKL PWTSCDNPWN TENCMQVTSE NFTELATSPA KEFFERKVLE SYKGNGLDFM 
241:	GPVKPTLALC VFGVFVLVYF SLWKGVRSAG KVVWVTALAP YVVLIILLVR GVSLPGADEG 
301:	IKYYLTPEWH KLKNSKVWID AASQIFFSLG PGFGTLLALS SYNKFNNNCY RDALITSSIN 
361:	CLTSFLAGFV IFSVLGYMAY VQKTSIDKVG LEGPGLVFIV YPEAIATMSG SVFWSIIFFL 
421:	MLITLGLDST FGGLEAMITA LCDEYPRVIG RRRELFVLLL LAFIFLCALP TMTYGGVVLV 
481:	NFLNVYGPGL AILFVVFVEA AGVFWFYGVD RFSSDVEQML GSKPGLFWRI CWTYISPVFL 
541:	LTIFIFSIMG YKEMLGEEYY YPDWSYQVGW AVTCSSVLCI PMYIIYKFFF ASKGGCRQRL 
601:	QESFQPEDNC GSVVPGQQGT SV