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2.A.22.2.1
Proline:Na+ symporter

Accession Number:P28573
Protein Name:NTPR aka SLC6A7
Length:637
Molecular Weight:71091.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Proline, Na+

Cross database links:

Genevestigator: P28573
eggNOG: maNOG05150
RefSeq: NP_446448.2   
Entrez Gene ID: 117100   
Pfam: PF00209   
KEGG: rno:117100   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0015193 F:L-proline transmembrane transporter activity
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0006836 P:neurotransmitter transport
GO:0015824 P:proline transport

References (1)

[1] “Molecular cloning and expression of a high affinity L-proline transporter expressed in putative glutamatergic pathways of rat brain.”  Fremeau R.T. Jr.et.al.   1350201

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MKKLQEAHLR KPVTPDLLMT PSDQGDVDLD VDFAADRGNW TGKLDFLLSC IGYCVGLGNV 
61:	WRFPYRAYTN GGGAFLVPYF LMLAICGIPL FFLELSLGQF SSLGPLAVWK ISPLFKGAGA 
121:	AMLLIVGLVA IYYNMIIAYV LFYLFASLTS NLPWEHCGNW WNTERCLEHR GPKDGNGALP 
181:	LNLSSTVSPS EEYWSRYVLH IQGSQGIGRP GEIRWNLCLC LLLAWVIVFL CILKGVKSSG 
241:	KVVYFTATFP YLILLMLLVR GVTLPGAWKG IQFYLTPQFH HLLSSKVWIE AALQIFYSLG 
301:	VGFGGLLTFA SYNTFHQNIY RDTFIVTLGN AITSILAGFA IFSVLGYMSQ ELGVPVDQVA 
361:	KAGPGLAFVI YPQAMTMLPL SPFWSFLFFF MLLTLGLDSQ FAFLETIVTA VTDEFPYYLR 
421:	PKKAVFSGLI CVAMYLMGLI LTTDGGMYWL VLLDDYSASF GLMVVVITTC LAVTRVYGIQ 
481:	RFCRDIHMML GFKPGLYFRA CWLFLSPATL LALLVYSIVK YQPSEYGSYR FPAWAELLGI 
541:	LMGLLSCLMI PAGMLVAVLR EEGSLWERLQ QASRPAIDWG PSLEENRTGM YVATLAGSQS 
601:	PKPLMVHMRK YGGITSFENT AIEVDREIAE EEEESMM