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2.A.22.2.13
Sodium-dependent nutrient amino acid transporter 1 (DmNAAT1)

Accession Number:Q9W4C5
Protein Name:Sodium-dependent nutrient amino acid transporter 1
Length:641
Molecular Weight:71762.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Amino acids, Na+

Cross database links:

eggNOG: COG0733
HEGENOM: HOG000264185
Entrez Gene ID: 31457   
Pfam: PF00209   
KEGG: dme:Dmel_CG3252   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0042943 F:D-amino acid transmembrane transporter activity
GO:0015179 F:L-amino acid transmembrane transporter activity
GO:0005326 F:neurotransmitter transporter activity
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0015175 F:neutral amino acid transmembrane transporter activity
GO:0005283 F:sodium:amino acid symporter activity

References (5)

[1] “The invertebrate B(0) system transporter, D. melanogaster NAT1, has unique d-amino acid affinity and mediates gut and brain functions.”  Miller M.M.et.al.   18718864
[2] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[3] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[4] “A Drosophila full-length cDNA resource.”  Stapleton M.et.al.   12537569
[5] “Identification of N-glycosylated proteins from the central nervous system of Drosophila melanogaster.”  Koles K.et.al.   17893096

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MELKGVQPSN GSSNGSGNGA TNAASTEKTD AEKPTAERTN WGNGLEFLMS CISVSVGLGN 
61:	VWRFPFTAYE NGGGAFLIPY IIVLFLIGKP MYYLEMIMGQ FTSQGTVKIW SVVPGFVGVG 
121:	YGQAFGTICI ISYYSSLLAL TLYYLFVSFQ SELPWSYCRD EWTNCVNSRP QEYVDNLLTG 
181:	VSLANESARN LSGIVANDET EKLQSSSELY FLNVVIKEKL DISDGVGDPD WKLTLALFVA 
241:	WVVIFLVIMR GVKSSGKAAY FLALFPYVVL FVLLIRAVTL EGARDGILFF LEPQWGELLN 
301:	PTVWKEAVVQ CFFSLAVGSG PIIMFASYNR FDHGIYRDAM IVTTLDTLTS LLGGITIFAI 
361:	LGNLAHNLQI ENIRDVVRSG TGLAFISYPD AISKFQAVPQ LFSVLFFFML FVLGIGSIVA 
421:	LQSTIVTIIC DQFKGWKYWK VALTTSVCGF LMGLVYVTPG GQWILTLVDF YGGTYVVFIL 
481:	AIFELAGIVW VYGLQNFCDD IEFMCNRRVS LYWRVCWSFF TPVMMIIIFI YSMVTIEPIK 
541:	YSELYFPEAA NIAGWLLFAI GAAQFPLWGL WYISRHPQGT YWKSLKASLK PSDRWGPANP 
601:	EIRREWVIFK NQKAAQRATQ KDTSKLGFFW RKVANFCGSN K